ID   I6_VARV                 Reviewed;         382 AA.
AC   P0DOM0; P33002;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2019, sequence version 1.
DT   23-FEB-2022, entry version 12.
DE   RecName: Full=Telomere-binding protein I6;
GN   ORFNames=I6L;
OS   Variola virus.
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=10255;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Bangladesh-1975;
RX   PubMed=8264798; DOI=10.1038/366748a0;
RA   Massung R.F., Esposito J.J., Liu L.I., Qi J., Utterback T.R., Knight J.C.,
RA   Aubin L., Yuran T.E., Parsons J.M., Loparev V.N., Selivanov N.A.,
RA   Cavallaro K.F., Kerlavage A.R., Mahy B.W.J., Venter J.C.;
RT   "Potential virulence determinants in terminal regions of variola smallpox
RT   virus genome.";
RL   Nature 366:748-751(1993).
CC   -!- FUNCTION: Binds to the hairpin form of the viral telomeric sequence.
CC       Might direct genome encapsidation into the virus particle (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}. Note=Present in the virus
CC       core. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae I6 family. {ECO:0000305}.
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DR   EMBL; L22579; AAA60808.1; -; Genomic_DNA.
DR   PIR; T28498; T28498.
DR   RefSeq; NP_042104.1; NC_001611.1.
DR   GeneID; 1486461; -.
DR   KEGG; vg:1486461; -.
DR   Proteomes; UP000119805; Genome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0016032; P:viral process; IEA:InterPro.
DR   InterPro; IPR007674; Poxvirus_36kDa_major_membrane.
DR   InterPro; IPR022219; Poxvirus_I6_C.
DR   Pfam; PF12562; DUF3746; 1.
DR   Pfam; PF04595; Pox_I6; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Virion.
FT   CHAIN           1..382
FT                   /note="Telomere-binding protein I6"
FT                   /id="PRO_0000448202"
SQ   SEQUENCE   382 AA;  43500 MW;  A1C63FE56CCA7D2D CRC64;
     MNNFVKQVAS KSLKPTKKLS PSDEVISLNE CIISFNLDNF YYCNDGLFTK PINTPEDVLK
     SLLIMESFAY EKMIIKGLIK ILISRAYIND IYFTPFGWLT GIDDDPETHV VIKIIFNSSL
     ISIKSQVIEY LKPYNVNNLS VLTTEKELSI NTFNVPDSIP MSIISFFPFD TDFILVILFF
     GVYNDSYCGI SYISPKERLP YIIEILKPLM SEINMLSDEI GRTSSIRIFN STSVKKFPTN
     TLTSICEIVY SFDESSFPTP KTFTPLNASP YIPKKIVSLL DLPSNVEIKA ISRGGVDFIT
     HINNKRLNTI LVIAKDNFLK NSTFSGTFIK ENIIWKGIYT YRIIKSSFPV PTIKSVTNKK
     KICKKHCFVN SQYTTRTLSH IL