ID   IAA1_STRGS              Reviewed;          78 AA.
AC   P01093;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 2.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Alpha-amylase inhibitor Haim-1;
DE   AltName: Full=Haim I;
OS   Streptomyces griseosporeus.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1910;
RN   [1]
RP   PROTEIN SEQUENCE, AND DISULFIDE BONDS.
RC   STRAIN=YM-25;
RX   PubMed=3875608; DOI=10.1093/oxfordjournals.jbchem.a135157;
RA   Murai H., Hara S., Ikenaka T., Goto A., Arai M., Murao S.;
RT   "Amino acid sequence of protein alpha-amylase inhibitor from Streptomyces
RT   griseosporeus YM-25.";
RL   J. Biochem. 97:1129-1133(1985).
RN   [2]
RP   STRUCTURE BY NMR.
RC   STRAIN=YM-25;
RX   PubMed=2229019; DOI=10.1093/oxfordjournals.jbchem.a123175;
RA   Yoshida M., Nakai T., Fukuhara K., Saitoh S., Yoshikawa W., Kobayashi Y.,
RA   Nakamura H.;
RT   "Three-dimensional structure of an alpha-amylase inhibitor HAIM as
RT   determined by nuclear magnetic resonance methods.";
RL   J. Biochem. 108:158-165(1990).
RN   [3]
RP   CRYSTALLIZATION.
RX   PubMed=8188627; DOI=10.1093/oxfordjournals.jbchem.a124295;
RA   Miyagawa M., Fukuhara K., Katayanagi K., Ishimaru K., Morikawa K.,
RA   Matsuzaki T., Sato Y., Hara S., Ikenaka T., Arai M., Murao S.;
RT   "Crystallization and preliminary crystallographic data of the alpha-amylase
RT   inhibitors, Haim I and Paim I.";
RL   J. Biochem. 115:168-170(1994).
CC   -!- FUNCTION: Inhibits mammalian alpha-amylases specifically but has no
CC       action on plant and microbial alpha-amylases.
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DR   PIR; JX0297; JX0297.
DR   AlphaFoldDB; P01093; -.
DR   BMRB; P01093; -.
DR   SMR; P01093; -.
DR   GO; GO:0015066; F:alpha-amylase inhibitor activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.20; -; 1.
DR   InterPro; IPR000833; A-amylase_inhib.
DR   InterPro; IPR036379; A-amylase_inhib_sf.
DR   Pfam; PF01356; A_amylase_inhib; 1.
DR   PIRSF; PIRSF001658; Amylase_inhib; 1.
DR   SMART; SM00783; A_amylase_inhib; 1.
DR   SUPFAM; SSF49498; SSF49498; 1.
PE   1: Evidence at protein level;
KW   Alpha-amylase inhibitor; Direct protein sequencing; Disulfide bond.
FT   CHAIN           1..78
FT                   /note="Alpha-amylase inhibitor Haim-1"
FT                   /id="PRO_0000203593"
FT   DISULFID        11..27
FT                   /evidence="ECO:0000269|PubMed:3875608"
FT   DISULFID        45..72
FT                   /evidence="ECO:0000269|PubMed:3875608"
SQ   SEQUENCE   78 AA;  8122 MW;  C3F5FC6B940A7E57 CRC64;
     DAGNRIAAPA CVHFTADWRY TFVTNDCSID YSVTVAYGDG TDVPCRSANP GDILTFPGYG
     TRGNEVLGAV LCATDGSA