ID   IAA1_STROI              Reviewed;          73 AA.
AC   P09921;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Alpha-amylase inhibitor Paim-1;
DE   AltName: Full=Pig pancreatic alpha-amylase inhibitor of microbes I;
DE            Short=Paim I;
OS   Streptomyces olivaceoviridis (Streptomyces corchorusii).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1921;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=3501315; DOI=10.1021/bi00394a029;
RA   Hirayama K., Takahashi R., Akashi S., Fukuhara K., Oouchi N., Murai A.,
RA   Arai M., Murao S., Tanaka K., Nojima I.;
RT   "Primary structure of Paim I, an alpha-amylase inhibitor from Streptomyces
RT   corchorushii, determined by the combination of Edman degradation and fast
RT   atom bombardment mass spectrometry.";
RL   Biochemistry 26:6483-6488(1987).
CC   -!- FUNCTION: Inhibits mammalian alpha-amylases specifically but has no
CC       action on plant and microbial alpha-amylases.
CC   -!- MISCELLANEOUS: PAIM I inhibits alpha-amylases from pig, dog, cow,
CC       horse, but has no activity against human salivary and pancreatic
CC       amylases.
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DR   AlphaFoldDB; P09921; -.
DR   SMR; P09921; -.
DR   PRIDE; P09921; -.
DR   GO; GO:0015066; F:alpha-amylase inhibitor activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.20; -; 1.
DR   InterPro; IPR000833; A-amylase_inhib.
DR   InterPro; IPR036379; A-amylase_inhib_sf.
DR   Pfam; PF01356; A_amylase_inhib; 1.
DR   PIRSF; PIRSF001658; Amylase_inhib; 1.
DR   SMART; SM00783; A_amylase_inhib; 1.
DR   SUPFAM; SSF49498; SSF49498; 1.
PE   1: Evidence at protein level;
KW   Alpha-amylase inhibitor; Direct protein sequencing; Disulfide bond.
FT   CHAIN           1..73
FT                   /note="Alpha-amylase inhibitor Paim-1"
FT                   /id="PRO_0000203591"
FT   DISULFID        8..24
FT                   /evidence="ECO:0000250"
FT   DISULFID        42..70
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   73 AA;  7424 MW;  0AB2E59906192C3B CRC64;
     ASEPAPACVV MYESWRYTTA ANNCADTVSV SVAYQDGATG PCATLPPGAV TTVGEGYLGE
     HGHPDHLALC PSS