ID   IAA2_STRGS              Reviewed;         120 AA.
AC   P20078;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Alpha-amylase inhibitor Haim-2;
DE   AltName: Full=Haim II;
DE   Flags: Precursor;
OS   Streptomyces griseosporeus.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1910;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=YM-25;
RX   PubMed=3262610; DOI=10.1128/jb.170.10.4451-4457.1988;
RA   Nagaso H., Saito S., Saito H., Takahashi H.;
RT   "Nucleotide sequence and expression of a Streptomyces griseosporeus
RT   proteinaceous alpha-amylase inhibitor (HaimII) gene.";
RL   J. Bacteriol. 170:4451-4457(1988).
RN   [2]
RP   PROTEIN SEQUENCE OF 38-120.
RC   STRAIN=YM-25;
RX   PubMed=3875608; DOI=10.1093/oxfordjournals.jbchem.a135157;
RA   Murai H., Hara S., Ikenaka T., Goto A., Arai M., Murao S.;
RT   "Amino acid sequence of protein alpha-amylase inhibitor from Streptomyces
RT   griseosporeus YM-25.";
RL   J. Biochem. 97:1129-1133(1985).
CC   -!- FUNCTION: Inhibits mammalian alpha-amylases specifically but has no
CC       action on plant and microbial alpha-amylases.
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DR   EMBL; M22620; AAA50324.1; -; Genomic_DNA.
DR   PIR; A01333; WISMAG.
DR   AlphaFoldDB; P20078; -.
DR   BMRB; P20078; -.
DR   SMR; P20078; -.
DR   GO; GO:0015066; F:alpha-amylase inhibitor activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.20; -; 1.
DR   InterPro; IPR000833; A-amylase_inhib.
DR   InterPro; IPR036379; A-amylase_inhib_sf.
DR   Pfam; PF01356; A_amylase_inhib; 1.
DR   PIRSF; PIRSF001658; Amylase_inhib; 1.
DR   SMART; SM00783; A_amylase_inhib; 1.
DR   SUPFAM; SSF49498; SSF49498; 1.
PE   1: Evidence at protein level;
KW   Alpha-amylase inhibitor; Direct protein sequencing; Disulfide bond; Signal.
FT   SIGNAL          1..32
FT                   /evidence="ECO:0000305"
FT   CHAIN           33..120
FT                   /note="Alpha-amylase inhibitor Haim-2"
FT                   /id="PRO_0000014342"
FT   DISULFID        43..59
FT   DISULFID        77..104
SQ   SEQUENCE   120 AA;  12624 MW;  4FF2214E224441A7 CRC64;
     MKRYVCSTFV ACVMVLCVIP ASGAAAHEAV AEDAGNRIAA PACVHFTADW RYTFVTNDCS
     IDYSVTVAYG DGTDVPCRSA NPGDILTFPG YGTRGNEVLG AVLCATDGSA LPVDRERAVR