IAA6_PEA
ID IAA6_PEA Reviewed; 179 AA.
AC P49680;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 25-MAY-2022, entry version 65.
DE RecName: Full=Auxin-induced protein IAA6;
GN Name=IAA6;
OS Pisum sativum (Garden pea).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Fabeae; Pisum.
OX NCBI_TaxID=3888;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC STRAIN=cv. Alaska;
RX PubMed=8411182; DOI=10.1006/jmbi.1993.1555;
RA Oeller P.W., Keller J.A., Parks J.E., Silbert J.E., Theologis A.;
RT "Structural characterization of the early indoleacetic acid-inducible
RT genes, PS-IAA4/5 and PS-IAA6, of pea (Pisum sativum L.).";
RL J. Mol. Biol. 233:789-798(1993).
CC -!- FUNCTION: Aux/IAA proteins are short-lived transcriptional factors that
CC function as repressors of early auxin response genes at low auxin
CC concentrations. Repression is thought to result from the interaction
CC with auxin response factors (ARFs), proteins that bind to the auxin-
CC responsive promoter element (AuxRE). Formation of heterodimers with ARF
CC proteins may alter their ability to modulate early auxin response genes
CC expression (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homodimers and heterodimers. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- INDUCTION: By auxin.
CC -!- DOMAIN: The N-terminal half of the protein contains two conserved
CC domains I and II. Domain I includes a slightly degenerated ERF-
CC associated amphiphilic repression (EAR) motif which seems to be
CC involved in the activity of transcriptional repression. Domain II is
CC required for the correct degradation of the protein through the SCF-
CC mediated ubiquitin-proteasome pathway. Interactions between Aux/IAA
CC proteins and auxin response factors (ARFs) occur through their C-
CC terminal dimerization domains III and IV (By similarity).
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the Aux/IAA family. {ECO:0000305}.
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DR EMBL; X68218; CAA48300.1; -; Genomic_DNA.
DR EMBL; X68217; CAA48299.1; -; mRNA.
DR PIR; S39078; S39078.
DR AlphaFoldDB; P49680; -.
DR SMR; P49680; -.
DR ELM; P49680; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0009734; P:auxin-activated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR InterPro; IPR033389; AUX/IAA_dom.
DR InterPro; IPR003311; AUX_IAA.
DR InterPro; IPR000270; PB1_dom.
DR PANTHER; PTHR31734; PTHR31734; 1.
DR Pfam; PF02309; AUX_IAA; 1.
DR PROSITE; PS51745; PB1; 1.
PE 2: Evidence at transcript level;
KW Auxin signaling pathway; Nucleus; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..179
FT /note="Auxin-induced protein IAA6"
FT /id="PRO_0000112862"
FT DOMAIN 75..163
FT /note="PB1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01081"
FT REGION 31..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 13..17
FT /note="EAR-like (transcriptional repression)"
SQ SEQUENCE 179 AA; 20331 MW; 0D212F384D100D7E CRC64;
MAREGLGLEI TELRLGLSCG EPKKNEKKRM FSEIDGGVEE NGGSGDRKSV DKKNQVVGWP
PVCSYRKKNM NEGSKMYMKV SMDGAPYLRK IDLCLHKGYL ELALALEKLF DCCGIEEALK
DAENCEHVPI YEDKDGDWML VGDVPWEMFI ESCKRLRIMK RSDAKGFDLQ PKGSLKRFI
