IAAC1_WHEAT
ID IAAC1_WHEAT Reviewed; 145 AA.
AC P16850;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1990, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Alpha-amylase/trypsin inhibitor CM1;
DE AltName: Full=Chloroform/methanol-soluble protein CM1;
DE Flags: Precursor;
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Chinese Spring; TISSUE=Endosperm;
RX PubMed=2102861; DOI=10.1007/bf00016517;
RA Garcia-Maroto F., Marana C., Mena M., Garcia-Olmedo F., Carbonero P.;
RT "Cloning of cDNA and chromosomal location of genes encoding the three types
RT of subunits of the wheat tetrameric inhibitor of insect alpha-amylase.";
RL Plant Mol. Biol. 14:845-853(1990).
RN [2]
RP PROTEIN SEQUENCE OF 26-53.
RC STRAIN=cv. Candeal;
RA Barber D., Sanchez-Monge R., Garcia-Olmedo F., Salcedo G., Mendez E.;
RT "Evolutionary implications of sequential homologies among members of the
RT trypsin / alpha-amylase inhibitor family (CM-proteins) in wheat and
RT barley.";
RL Biochim. Biophys. Acta 873:147-151(1986).
CC -!- FUNCTION: Alpha-amylase/trypsin inhibitor. It could be involved in
CC insect defense mechanisms.
CC -!- SUBUNIT: Subunit of the tetrameric inhibitor.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Endosperm.
CC -!- MISCELLANEOUS: CM proteins would be involved in the cooking quality of
CC pasta.
CC -!- SIMILARITY: Belongs to the protease inhibitor I6 (cereal trypsin/alpha-
CC amylase inhibitor) family. {ECO:0000305}.
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DR EMBL; X17575; CAA35598.1; -; mRNA.
DR PIR; A25310; A25310.
DR PIR; S10027; S10027.
DR AlphaFoldDB; P16850; -.
DR SMR; P16850; -.
DR Allergome; 8188; Tri a 29.
DR MEROPS; I06.004; -.
DR PRIDE; P16850; -.
DR Proteomes; UP000019116; Unplaced.
DR ExpressionAtlas; P16850; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0015066; F:alpha-amylase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR CDD; cd00261; AAI_SS; 1.
DR Gene3D; 1.10.110.10; -; 1.
DR InterPro; IPR044723; AAI_SS_dom.
DR InterPro; IPR006106; Allergen/soft/tryp_amyl_inhib.
DR InterPro; IPR006105; Allergen/tryp_amyl_inhib_CS.
DR InterPro; IPR036312; Bifun_inhib/LTP/seed_sf.
DR InterPro; IPR016140; Bifunc_inhib/LTP/seed_store.
DR Pfam; PF00234; Tryp_alpha_amyl; 1.
DR PRINTS; PR00808; AMLASEINHBTR.
DR SMART; SM00499; AAI; 1.
DR SUPFAM; SSF47699; SSF47699; 1.
DR PROSITE; PS00426; CEREAL_TRYP_AMYL_INH; 1.
PE 1: Evidence at protein level;
KW Alpha-amylase inhibitor; Direct protein sequencing; Protease inhibitor;
KW Reference proteome; Secreted; Serine protease inhibitor; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000269|Ref.2"
FT CHAIN 26..145
FT /note="Alpha-amylase/trypsin inhibitor CM1"
FT /id="PRO_0000014344"
SQ SEQUENCE 145 AA; 15517 MW; 119EDBD8C1229672 CRC64;
MASKSSISPL LLATVLVSVF AAATATGPYC YAGMGLPINP LEGCREYVAQ QTCGISISGS
AVSTEPGNTP RDRCCKELYD ASQHCRCEAV RYFIGRRSDP NSSVLKDLPG CPREPQRDFA
KVLVTSGHCN VMTVHNAPYC LGLDI
