ID   IAA_KITAU               Reviewed;          36 AA.
AC   P04082;
DT   01-NOV-1986, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1986, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Alpha-amylase inhibitor AI-3688;
DE   Flags: Fragment;
OS   Kitasatospora aureofaciens (Streptomyces aureofaciens).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Kitasatospora.
OX   NCBI_TaxID=1894;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   STRAIN=DSM 2790;
RX   PubMed=2581812; DOI=10.1016/0014-5793(85)80767-5;
RA   Vertesy L., Tripier D.;
RT   "Isolation and structure elucidation of an alpha-amylase inhibitor, AI-
RT   3688, from Streptomyces aureofaciens.";
RL   FEBS Lett. 185:187-190(1985).
CC   -!- FUNCTION: Inhibits mammalian alpha-amylases specifically but has no
CC       action on plant and microbial alpha-amylases.
CC   -!- MISCELLANEOUS: This protein is an effective inhibitor of pancreatic
CC       alpha-amylase. It is 5 times less effective against human salivary
CC       amylase.
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DR   PIR; A01331; WISMAA.
DR   AlphaFoldDB; P04082; -.
DR   SMR; P04082; -.
DR   GO; GO:0015066; F:alpha-amylase inhibitor activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.20; -; 1.
DR   InterPro; IPR000833; A-amylase_inhib.
DR   InterPro; IPR036379; A-amylase_inhib_sf.
DR   Pfam; PF01356; A_amylase_inhib; 1.
DR   SMART; SM00783; A_amylase_inhib; 1.
DR   SUPFAM; SSF49498; SSF49498; 1.
PE   1: Evidence at protein level;
KW   Alpha-amylase inhibitor; Direct protein sequencing; Disulfide bond.
FT   CHAIN           1..>36
FT                   /note="Alpha-amylase inhibitor AI-3688"
FT                   /id="PRO_0000203590"
FT   DISULFID        9..25
FT                   /evidence="ECO:0000269|PubMed:2581812"
FT   NON_TER         36
SQ   SEQUENCE   36 AA;  3938 MW;  64A65B321BE3A829 CRC64;
     ATGSPAPDCV ESFQSWRYTD VRNGCSDAVT VVVQYE