ID   IAA_STRRO               Reviewed;          76 AA.
AC   P07512;
DT   01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1988, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Alpha-amylase inhibitor Z-2685;
OS   Streptomyces rochei (Streptomyces parvullus).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces rochei group.
OX   NCBI_TaxID=1928;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=3879177; DOI=10.1515/bchm3.1985.366.2.1161;
RA   Hofmann O., Vertesy L., Braunitzer G.;
RT   "The primary structure of alpha-amylase inhibitor Z-2685 from Streptomyces
RT   parvullus FH-1641. Sequence homology between inhibitor and alpha-amylase.";
RL   Biol. Chem. Hoppe-Seyler 366:1161-1168(1985).
CC   -!- FUNCTION: Inhibits mammalian alpha-amylases specifically but has no
CC       action on plant and microbial alpha-amylases.
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DR   PIR; A24694; A24694.
DR   PDB; 2KER; NMR; -; A=1-76.
DR   PDBsum; 2KER; -.
DR   AlphaFoldDB; P07512; -.
DR   BMRB; P07512; -.
DR   SMR; P07512; -.
DR   EvolutionaryTrace; P07512; -.
DR   GO; GO:0015066; F:alpha-amylase inhibitor activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.20; -; 1.
DR   InterPro; IPR000833; A-amylase_inhib.
DR   InterPro; IPR036379; A-amylase_inhib_sf.
DR   Pfam; PF01356; A_amylase_inhib; 1.
DR   PIRSF; PIRSF001658; Amylase_inhib; 1.
DR   SMART; SM00783; A_amylase_inhib; 1.
DR   SUPFAM; SSF49498; SSF49498; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Alpha-amylase inhibitor; Direct protein sequencing;
KW   Disulfide bond.
FT   CHAIN           1..76
FT                   /note="Alpha-amylase inhibitor Z-2685"
FT                   /id="PRO_0000203594"
FT   DISULFID        9..25
FT                   /evidence="ECO:0000250"
FT   DISULFID        43..70
FT                   /evidence="ECO:0000250"
FT   STRAND          5..9
FT                   /evidence="ECO:0007829|PDB:2KER"
FT   STRAND          11..14
FT                   /evidence="ECO:0007829|PDB:2KER"
FT   STRAND          16..22
FT                   /evidence="ECO:0007829|PDB:2KER"
FT   STRAND          25..27
FT                   /evidence="ECO:0007829|PDB:2KER"
FT   STRAND          29..37
FT                   /evidence="ECO:0007829|PDB:2KER"
FT   STRAND          44..46
FT                   /evidence="ECO:0007829|PDB:2KER"
FT   STRAND          53..55
FT                   /evidence="ECO:0007829|PDB:2KER"
FT   STRAND          64..69
FT                   /evidence="ECO:0007829|PDB:2KER"
SQ   SEQUENCE   76 AA;  8130 MW;  196162FF7595D292 CRC64;
     ATGSPVAECV EYFQSWRYTD VHNGCADAVS VTVEYTHGQW APCRVIEPGG WATFAGYGTD
     GNYVTGLHTC DPATPS