ID   IAC1_BOVIN              Reviewed;          63 AA.
AC   P01000;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=Acrosin inhibitor 1;
DE   AltName: Full=Acrosin inhibitor I;
DE   AltName: Full=BUSI-I;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=6365719; DOI=10.1515/bchm2.1983.364.2.1665;
RA   Meloun B., Cechova D., Jonakova V.;
RT   "Homologies in the structures of bull seminal plasma acrosin inhibitors and
RT   comparison with other homologous proteinase inhibitors of the Kazal type.";
RL   Hoppe-Seyler's Z. Physiol. Chem. 364:1665-1670(1983).
CC   -!- FUNCTION: Strong inhibitor of acrosin.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Seminal plasma.
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DR   PIR; A01234; XTBO1.
DR   AlphaFoldDB; P01000; -.
DR   SMR; P01000; -.
DR   MEROPS; I01.014; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR002350; Kazal_dom.
DR   InterPro; IPR036058; Kazal_dom_sf.
DR   Pfam; PF00050; Kazal_1; 1.
DR   SMART; SM00280; KAZAL; 1.
DR   SUPFAM; SSF100895; SSF100895; 1.
DR   PROSITE; PS00282; KAZAL_1; 1.
DR   PROSITE; PS51465; KAZAL_2; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Protease inhibitor;
KW   Reference proteome; Secreted; Serine protease inhibitor.
FT   CHAIN           1..63
FT                   /note="Acrosin inhibitor 1"
FT                   /id="PRO_0000073032"
FT   DOMAIN          8..63
FT                   /note="Kazal-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT   SITE            23..24
FT                   /note="Reactive bond"
FT   DISULFID        14..43
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT   DISULFID        21..40
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT   DISULFID        29..61
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
SQ   SEQUENCE   63 AA;  7379 MW;  A026686988ABDEB2 CRC64;
     EIYFEPDFGF PPDCKVYTEA CTREYNPICD SAAKTYSNEC TFCNEKMNND ADIHFNHFGE
     CEY