ID   IACA_PIG                Reviewed;          65 AA.
AC   P00999;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Seminal plasma acrosin inhibitor A1;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   PROTEIN SEQUENCE, GLYCOSYLATION AT SER-12 AND SER-62, AND DISULFIDE BONDS.
RA   Tschesche H., Kupfer S., Klauser R., Fink E., Fritz H.;
RL   (In) Peeters H. (eds.);
RL   Protides of the biological fluids, Proc. 23th colloquium, pp.255-266,
RL   Pergamon Press, New York (1976).
CC   -!- FUNCTION: Inhibits acrosin.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Seminal plasma.
CC   -!- PTM: The identity of the O-linked saccharides are not reported in
CC       Ref.1. The O-linked polysaccharides on Ser-12 and Ser-62 are probably
CC       the mucin type linked to GalNAc. {ECO:0000269|Ref.1}.
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DR   PIR; A01233; XTPG1.
DR   AlphaFoldDB; P00999; -.
DR   SMR; P00999; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR002350; Kazal_dom.
DR   InterPro; IPR036058; Kazal_dom_sf.
DR   Pfam; PF00050; Kazal_1; 1.
DR   SMART; SM00280; KAZAL; 1.
DR   SUPFAM; SSF100895; SSF100895; 1.
DR   PROSITE; PS00282; KAZAL_1; 1.
DR   PROSITE; PS51465; KAZAL_2; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Glycoprotein;
KW   Protease inhibitor; Reference proteome; Secreted;
KW   Serine protease inhibitor.
FT   CHAIN           1..65
FT                   /note="Seminal plasma acrosin inhibitor A1"
FT                   /id="PRO_0000073034"
FT   DOMAIN          1..59
FT                   /note="Kazal-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT   SITE            19..20
FT                   /note="Reactive bond"
FT   CARBOHYD        12
FT                   /note="O-linked (GalNAc...) serine"
FT                   /evidence="ECO:0000269|Ref.1"
FT   CARBOHYD        62
FT                   /note="O-linked (GalNAc...) serine"
FT                   /evidence="ECO:0000269|Ref.1"
FT   DISULFID        7..39
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798,
FT                   ECO:0000269|Ref.1"
FT   DISULFID        17..36
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798,
FT                   ECO:0000269|Ref.1"
FT   DISULFID        25..57
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798,
FT                   ECO:0000269|Ref.1"
SQ   SEQUENCE   65 AA;  7595 MW;  8DB22707CBD50480 CRC64;
     TRKQPNCNVY RSHLFFCTRQ MDPICGTNGK SYANPCIFCS EKGLRNQKFD FGHWGHCREY
     TSARS