ID   IACI_PESFW              Reviewed;         384 AA.
AC   A0A1J0HSR1; W3XL73;
DT   02-DEC-2020, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2017, sequence version 1.
DT   25-MAY-2022, entry version 7.
DE   RecName: Full=Transcription factor iacI {ECO:0000303|PubMed:29384350};
DE   AltName: Full=Iso-A82775C biosynthesis cluster protein I {ECO:0000303|PubMed:29384350};
GN   Name=iacI {ECO:0000303|PubMed:29384350}; ORFNames=PFICI_04046;
OS   Pestalotiopsis fici (strain W106-1 / CGMCC3.15140).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Xylariomycetidae; Xylariales; Sporocadaceae; Pestalotiopsis.
OX   NCBI_TaxID=1229662;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND BIOTECHNOLOGY.
RC   STRAIN=W106-1 / CGMCC3.15140;
RX   PubMed=29384350; DOI=10.1021/acschembio.7b01059;
RA   Pan Y., Liu L., Guan F., Li E., Jin J., Li J., Che Y., Liu G.;
RT   "Characterization of a prenyltransferase for iso-A82775C biosynthesis and
RT   generation of new congeners of chloropestolides.";
RL   ACS Chem. Biol. 13:703-711(2018).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=W106-1 / CGMCC3.15140;
RX   PubMed=25623211; DOI=10.1186/s12864-014-1190-9;
RA   Wang X., Zhang X., Liu L., Xiang M., Wang W., Sun X., Che Y., Guo L.,
RA   Liu G., Guo L., Wang C., Yin W.B., Stadler M., Zhang X., Liu X.;
RT   "Genomic and transcriptomic analysis of the endophytic fungus
RT   Pestalotiopsis fici reveals its lifestyle and high potential for synthesis
RT   of natural products.";
RL   BMC Genomics 16:28-28(2015).
CC   -!- FUNCTION: Transcription factor; part of the gene cluster that mediates
CC       the biosynthesis of iso-A82775C, a enylepoxycyclohexane and
CC       biosynthetic precursor of the chloropestolide anticancer natural
CC       products. {ECO:0000269|PubMed:29384350}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:29384350}.
CC   -!- BIOTECHNOLOGY: Iso-A82775C is a precursor for the biosynthesis of the
CC       anticancer natural products chloropestolides A to E via a Diesls-Alder
CC       reaction with maldoxin (PubMed:29384350). In the absence of the
CC       prenyltransferase iacE, siccayne accumulates instead of iso-A82775C and
CC       can also be condensed with maldoxin to produce chloropestolides H to K,
CC       which show also antibacterial and anticancer properties
CC       (PubMed:29384350). {ECO:0000269|PubMed:29384350}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ETS86021.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; KU963195; APC57600.1; -; Genomic_DNA.
DR   EMBL; KI912110; ETS86021.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; XP_007830818.1; XM_007832627.1.
DR   AlphaFoldDB; A0A1J0HSR1; -.
DR   EnsemblFungi; ETS86021; ETS86021; PFICI_04046.
DR   GeneID; 19269059; -.
DR   KEGG; pfy:PFICI_04046; -.
DR   eggNOG; ENOG502SNVB; Eukaryota.
DR   HOGENOM; CLU_015493_0_0_1; -.
DR   OrthoDB; 416512at2759; -.
DR   Proteomes; UP000030651; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR021858; Fun_TF.
DR   Pfam; PF11951; Fungal_trans_2; 1.
PE   1: Evidence at protein level;
KW   Nucleus; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..384
FT                   /note="Transcription factor iacI"
FT                   /id="PRO_0000451382"
SQ   SEQUENCE   384 AA;  42376 MW;  B9C33A4B9DC17469 CRC64;
     MSLLDLPTLW NASGVEALDS DLFEYFCCVA SGSLPTFGHD ATALRNILVR TALEGETASA
     AAVLQALLAF SSLHRYGLQP QALELKITAL GSLAKGSFTP GLGTKETIEH IAAGMLLSSF
     EVHQSSCTSG HWTGYLGGVK TITDMSSVKT LLQFSSDVAV LLDWVHYHNV LARFSLLYWN
     GEETSEFPST PTNLLSSQDS SLPPPIYSMM DLLSQICDLS NSAIPTGTSD EVDNYKGFLK
     VLDWRIRSLP IKGDNDGEML LMKLYQLALL LFLNRSFEGL IDQPIRMQQQ IGQAFAILPR
     LSSCRQQFPI YVIGCEARTD EQRAAVLDLI TKTEKMSTSR SFNHCRTLLQ AVWTQDDLAE
     WDDISYRAKL TLVISRCAVA PIFV