ID   IACX2_WHEAT             Reviewed;         121 AA.
AC   Q43691;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Trypsin/alpha-amylase inhibitor CMX2;
DE   AltName: Full=ITRL-2;
DE   Flags: Precursor;
OS   Triticum aestivum (Wheat).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX   NCBI_TaxID=4565;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Chinese Spring; TISSUE=Endosperm;
RX   PubMed=7811982; DOI=10.1007/bf00040705;
RA   Sanchez de la Hoz P., Castagnaro A., Carbonero P.;
RT   "Sharp divergence between wheat and barley at loci encoding novel members
RT   of the trypsin/alpha-amylase inhibitors family.";
RL   Plant Mol. Biol. 26:1231-1236(1994).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the protease inhibitor I6 (cereal trypsin/alpha-
CC       amylase inhibitor) family. {ECO:0000305}.
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DR   EMBL; X75609; CAA53281.1; -; mRNA.
DR   AlphaFoldDB; Q43691; -.
DR   SMR; Q43691; -.
DR   Allergome; 11042; Tri a CMX.
DR   PRIDE; Q43691; -.
DR   Proteomes; UP000019116; Unplaced.
DR   ExpressionAtlas; Q43691; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   CDD; cd00261; AAI_SS; 1.
DR   Gene3D; 1.10.110.10; -; 1.
DR   InterPro; IPR044723; AAI_SS_dom.
DR   InterPro; IPR036312; Bifun_inhib/LTP/seed_sf.
DR   InterPro; IPR016140; Bifunc_inhib/LTP/seed_store.
DR   Pfam; PF00234; Tryp_alpha_amyl; 1.
DR   SUPFAM; SSF47699; SSF47699; 1.
PE   2: Evidence at transcript level;
KW   Protease inhibitor; Reference proteome; Secreted;
KW   Serine protease inhibitor; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..121
FT                   /note="Trypsin/alpha-amylase inhibitor CMX2"
FT                   /id="PRO_0000014349"
SQ   SEQUENCE   121 AA;  13889 MW;  55902141918CEFF5 CRC64;
     MAFKHQLILS TAILLAVLAA ASASFREQCV PGREITYESL NARREYAVRQ TCGYYLSAER
     QKRRCCDELS KVPELCWCEV LRILMDRRVT KEGVVKDSLL QDMSRCKKLT REFIAGIVGR
     E