ID   IAD1_ENTFA              Reviewed;          22 AA.
AC   P24803;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-1992, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Sex pheromone inhibitor determinant;
DE   AltName: Full=iAD1;
DE   Flags: Precursor;
GN   Name=iad; OrderedLocusNames=EF_A0005.1;
OS   Enterococcus faecalis (strain ATCC 700802 / V583).
OG   Plasmid pTEF1, and Plasmid pAD1.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Enterococcaceae;
OC   Enterococcus.
OX   NCBI_TaxID=226185;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   PLASMID=pAD1;
RX   PubMed=2128961; DOI=10.1016/0147-619x(90)90019-9;
RA   Clewell D.B., Pontius L.T., An F.Y., Ike Y., Suzuki A., Nakayama J.;
RT   "Nucleotide sequence of the sex pheromone inhibitor (iAD1) determinant of
RT   Enterococcus faecalis conjugative plasmid pAD1.";
RL   Plasmid 24:156-161(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700802 / V583; PLASMID=pTEF1;
RX   PubMed=12663927; DOI=10.1126/science.1080613;
RA   Paulsen I.T., Banerjei L., Myers G.S.A., Nelson K.E., Seshadri R.,
RA   Read T.D., Fouts D.E., Eisen J.A., Gill S.R., Heidelberg J.F., Tettelin H.,
RA   Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C.,
RA   DeBoy R.T., Durkin S.A., Kolonay J.F., Madupu R., Nelson W.C.,
RA   Vamathevan J.J., Tran B., Upton J., Hansen T., Shetty J., Khouri H.M.,
RA   Utterback T.R., Radune D., Ketchum K.A., Dougherty B.A., Fraser C.M.;
RT   "Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus
RT   faecalis.";
RL   Science 299:2071-2074(2003).
CC   -!- FUNCTION: Acts as a competitive inhibitor of the CAD1 pheromone.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- MISCELLANEOUS: IAD1 appears to be a component of its own signal
CC       sequence.
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DR   EMBL; M62888; AAA98039.1; -; Genomic_DNA.
DR   EMBL; AE016833; AAO83007.1; -; Genomic_DNA.
DR   PIR; A37391; A37391.
DR   RefSeq; NP_816936.1; NC_004669.1.
DR   RefSeq; WP_011109599.1; NZ_KE136530.1.
DR   AlphaFoldDB; P24803; -.
DR   EnsemblBacteria; AAO83007; AAO83007; EF_A00051.
DR   KEGG; efa:EFA0005.1; -.
DR   HOGENOM; CLU_3424700_0_0_9; -.
DR   Proteomes; UP000001415; Plasmid pTEF1.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   4: Predicted;
KW   Plasmid; Reference proteome; Secreted.
FT   PROPEP          1..14
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000021476"
FT   PEPTIDE         15..22
FT                   /note="Sex pheromone inhibitor determinant"
FT                   /id="PRO_0000021477"
SQ   SEQUENCE   22 AA;  2459 MW;  D0EAEBDF1BCD9D08 CRC64;
     MSKRAMKKII PLITLFVVTL VG