ID   IAH1_BOVIN              Reviewed;         249 AA.
AC   Q3SZ16;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Isoamyl acetate-hydrolyzing esterase 1 homolog;
DE            EC=3.1.-.-;
GN   Name=IAH1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable lipase. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the 'GDSL' lipolytic enzyme family. IAH1
CC       subfamily. {ECO:0000305}.
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DR   EMBL; BC103252; AAI03253.1; -; mRNA.
DR   RefSeq; NP_001029930.1; NM_001034758.1.
DR   AlphaFoldDB; Q3SZ16; -.
DR   SMR; Q3SZ16; -.
DR   STRING; 9913.ENSBTAP00000032777; -.
DR   PaxDb; Q3SZ16; -.
DR   PRIDE; Q3SZ16; -.
DR   Ensembl; ENSBTAT00000032849; ENSBTAP00000032777; ENSBTAG00000001140.
DR   GeneID; 614320; -.
DR   KEGG; bta:614320; -.
DR   CTD; 285148; -.
DR   VEuPathDB; HostDB:ENSBTAG00000001140; -.
DR   VGNC; VGNC:30016; IAH1.
DR   eggNOG; KOG3035; Eukaryota.
DR   GeneTree; ENSGT00390000008069; -.
DR   HOGENOM; CLU_051989_0_2_1; -.
DR   InParanoid; Q3SZ16; -.
DR   OMA; HEPAWEK; -.
DR   OrthoDB; 1226154at2759; -.
DR   TreeFam; TF328918; -.
DR   Proteomes; UP000009136; Chromosome 11.
DR   Bgee; ENSBTAG00000001140; Expressed in cortex of kidney and 108 other tissues.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1110; -; 1.
DR   InterPro; IPR045136; Iah1-like.
DR   InterPro; IPR013830; SGNH_hydro.
DR   InterPro; IPR036514; SGNH_hydro_sf.
DR   PANTHER; PTHR14209; PTHR14209; 1.
DR   Pfam; PF13472; Lipase_GDSL_2; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase; Lipid degradation; Lipid metabolism; Reference proteome.
FT   CHAIN           1..249
FT                   /note="Isoamyl acetate-hydrolyzing esterase 1 homolog"
FT                   /id="PRO_0000315722"
FT   ACT_SITE        24
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000250|UniProtKB:P41734"
FT   ACT_SITE        197
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250|UniProtKB:P41734"
FT   ACT_SITE        200
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250|UniProtKB:P41734"
FT   SITE            56
FT                   /note="Transition state stabilizer"
FT                   /evidence="ECO:0000250|UniProtKB:P41734"
FT   SITE            89
FT                   /note="Transition state stabilizer"
FT                   /evidence="ECO:0000250|UniProtKB:P41734"
FT   MOD_RES         63
FT                   /note="N6-succinyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9DB29"
SQ   SEQUENCE   249 AA;  27579 MW;  BF51C5E2DFD26DA6 CRC64;
     MALCEAVASG SPLVWPRVLL FGDSITQFSF QQGGWGASLA DMLVRKCDVL NRGFSGYNTR
     WAKIILPRLV RKGSGLDSPV AVTIFFGAND SALKDENPKQ HVPLEEFVAN LRSMVRYLRS
     VDVPEGRLIL ITPPPLCEAA WAQECLQQGC KLNRLNSVVG EYARACLQVA QDCGADALDL
     WSLMQKDGQD FSSYLSDGLH LSPKGNEFVF SHLWPLIEKK VSSLPFLLPY WRDIAEARPE
     LSLLGDGDH