IAH1_DANRE
ID IAH1_DANRE Reviewed; 238 AA.
AC Q503L4; Q5RFV5;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 2.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=Isoamyl acetate-hydrolyzing esterase 1 homolog;
DE EC=3.1.-.-;
GN Name=iah1; ORFNames=si:dkey-174c12.2;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Olfactory epithelium;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Probable lipase. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the 'GDSL' lipolytic enzyme family. IAH1
CC subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH95279.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; CR556709; CAI20729.1; -; Genomic_DNA.
DR EMBL; BC095279; AAH95279.1; ALT_INIT; mRNA.
DR RefSeq; NP_001020640.1; NM_001025469.1.
DR AlphaFoldDB; Q503L4; -.
DR SMR; Q503L4; -.
DR STRING; 7955.ENSDARP00000021046; -.
DR PaxDb; Q503L4; -.
DR Ensembl; ENSDART00000016702; ENSDARP00000021046; ENSDARG00000015765.
DR GeneID; 449926; -.
DR KEGG; dre:449926; -.
DR CTD; 285148; -.
DR ZFIN; ZDB-GENE-041008-186; iah1.
DR eggNOG; KOG3035; Eukaryota.
DR GeneTree; ENSGT00390000008069; -.
DR HOGENOM; CLU_051989_0_2_1; -.
DR InParanoid; Q503L4; -.
DR OMA; HEPAWEK; -.
DR OrthoDB; 1226154at2759; -.
DR PhylomeDB; Q503L4; -.
DR TreeFam; TF328918; -.
DR PRO; PR:Q503L4; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 17.
DR Bgee; ENSDARG00000015765; Expressed in mature ovarian follicle and 26 other tissues.
DR ExpressionAtlas; Q503L4; baseline and differential.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1110; -; 1.
DR InterPro; IPR045136; Iah1-like.
DR InterPro; IPR013830; SGNH_hydro.
DR InterPro; IPR036514; SGNH_hydro_sf.
DR PANTHER; PTHR14209; PTHR14209; 1.
DR Pfam; PF13472; Lipase_GDSL_2; 1.
PE 2: Evidence at transcript level;
KW Hydrolase; Lipid degradation; Lipid metabolism; Reference proteome.
FT CHAIN 1..238
FT /note="Isoamyl acetate-hydrolyzing esterase 1 homolog"
FT /id="PRO_0000315726"
FT ACT_SITE 18
FT /note="Nucleophile"
FT /evidence="ECO:0000250|UniProtKB:P41734"
FT ACT_SITE 189
FT /note="Proton donor"
FT /evidence="ECO:0000250|UniProtKB:P41734"
FT ACT_SITE 192
FT /note="Proton acceptor"
FT /evidence="ECO:0000250|UniProtKB:P41734"
FT SITE 50
FT /note="Transition state stabilizer"
FT /evidence="ECO:0000250|UniProtKB:P41734"
FT SITE 81
FT /note="Transition state stabilizer"
FT /evidence="ECO:0000250|UniProtKB:P41734"
FT CONFLICT 119
FT /note="N -> K (in Ref. 2; AAH95279)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 238 AA; 26548 MW; 758D71F0A528F624 CRC64;
MSALKRVIWP QIILFGDSIT QFAFQANGWG SELCHKLERK CDVINRGLSG YNTRWAKIVL
PRIVPVSDAP ISAVTVFFGA NDCALEDKNP TQHVPLQEFS ENLKDIVRFL VSKGVSNDNI
IFITPPPLLE ADWEKECLLK GSPLNRLNSV AGQYAQACVQ AAGESGVDVL DLWTLMQKDG
QDFSVYLSDG LHLSDKGNQF VAEHLWTLLE RRVSDLPFIL PYWGDVDPKC PESSLLCD
