IAH1_RAT
ID IAH1_RAT Reviewed; 249 AA.
AC Q711G3;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 2.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Isoamyl acetate-hydrolyzing esterase 1 homolog;
DE EC=3.1.-.-;
DE AltName: Full=Hypertrophic agonist-responsive protein B64;
GN Name=Iah1; Synonyms=Harpb64;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 27-106.
RC STRAIN=Sprague-Dawley;
RA Kemp T.J.;
RT "Identification of genes responsive to the hypertrophic agonists
RT phenylepherine and endothelin-1.";
RL Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Probable lipase. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the 'GDSL' lipolytic enzyme family. IAH1
CC subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAC87844.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AABR03049942; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJ344542; CAC87844.1; ALT_INIT; mRNA.
DR RefSeq; NP_001094010.1; NM_001100540.1.
DR AlphaFoldDB; Q711G3; -.
DR SMR; Q711G3; -.
DR STRING; 10116.ENSRNOP00000009824; -.
DR iPTMnet; Q711G3; -.
DR PhosphoSitePlus; Q711G3; -.
DR SwissPalm; Q711G3; -.
DR jPOST; Q711G3; -.
DR PaxDb; Q711G3; -.
DR PRIDE; Q711G3; -.
DR Ensembl; ENSRNOT00000087180; ENSRNOP00000068696; ENSRNOG00000060853.
DR GeneID; 298917; -.
DR KEGG; rno:298917; -.
DR CTD; 285148; -.
DR RGD; 727866; Iah1.
DR eggNOG; KOG3035; Eukaryota.
DR GeneTree; ENSGT00390000008069; -.
DR HOGENOM; CLU_051989_0_2_1; -.
DR InParanoid; Q711G3; -.
DR OMA; HEPAWEK; -.
DR OrthoDB; 1226154at2759; -.
DR PhylomeDB; Q711G3; -.
DR TreeFam; TF328918; -.
DR PRO; PR:Q711G3; -.
DR Proteomes; UP000002494; Chromosome 6.
DR Bgee; ENSRNOG00000060853; Expressed in adult mammalian kidney and 19 other tissues.
DR ExpressionAtlas; Q711G3; baseline and differential.
DR Genevisible; Q711G3; RN.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1110; -; 1.
DR InterPro; IPR045136; Iah1-like.
DR InterPro; IPR013830; SGNH_hydro.
DR InterPro; IPR036514; SGNH_hydro_sf.
DR PANTHER; PTHR14209; PTHR14209; 1.
DR Pfam; PF13472; Lipase_GDSL_2; 1.
PE 2: Evidence at transcript level;
KW Hydrolase; Lipid degradation; Lipid metabolism; Reference proteome.
FT CHAIN 1..249
FT /note="Isoamyl acetate-hydrolyzing esterase 1 homolog"
FT /id="PRO_0000315725"
FT ACT_SITE 24
FT /note="Nucleophile"
FT /evidence="ECO:0000250|UniProtKB:P41734"
FT ACT_SITE 197
FT /note="Proton donor"
FT /evidence="ECO:0000250|UniProtKB:P41734"
FT ACT_SITE 200
FT /note="Proton acceptor"
FT /evidence="ECO:0000250|UniProtKB:P41734"
FT SITE 56
FT /note="Transition state stabilizer"
FT /evidence="ECO:0000250|UniProtKB:P41734"
FT SITE 89
FT /note="Transition state stabilizer"
FT /evidence="ECO:0000250|UniProtKB:P41734"
FT MOD_RES 63
FT /note="N6-succinyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q9DB29"
FT CONFLICT 32
FT /note="Q -> R (in Ref. 2; CAC87844)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 249 AA; 28004 MW; 34A32D4F93F559B6 CRC64;
MSLCELAASG SSLLWPRVLL FGDSITQFSF QQGGWGTLLA DRLVRKCDVL NRGFSGYNTR
WAKIILPRII RKGAGLENPV AVTIFFGAND STLKDENPKQ HVPLDEYSAN LRDMVQYLRS
VDIPKERVIL ITPPPLCEAA WEKECILKGC KLNRLNVAVG EYAKACLQVA RDCGTDVLDL
WTLMQKDNQD FSSYLSDGLH LSPLGNEFLF FHLWPLLDKK VSSLPRLLPD WKDVEETKPE
LSLLGDGDH
