ID   APBB3_MOUSE             Reviewed;         486 AA.
AC   Q8R1C9;
DT   27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 134.
DE   RecName: Full=Amyloid-beta A4 precursor protein-binding family B member 3;
DE   AltName: Full=Protein Fe65-like 2;
DE            Short=Fe65L2;
GN   Name=Apbb3 {ECO:0000312|MGI:MGI:108404};
GN   Synonyms=Fe65l2 {ECO:0000312|MGI:MGI:108404};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May modulate the internalization of amyloid-beta precursor
CC       protein. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with APP (via intracellular domain) (By similarity).
CC       Interacts with APLP1 and APLP2 (via intracellular domain) (By
CC       similarity). {ECO:0000250|UniProtKB:O95704}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O95704}. Nucleus
CC       {ECO:0000250|UniProtKB:O95704}.
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DR   EMBL; BC024809; AAH24809.1; -; mRNA.
DR   CCDS; CCDS29157.1; -.
DR   RefSeq; NP_666197.1; NM_146085.1.
DR   AlphaFoldDB; Q8R1C9; -.
DR   SMR; Q8R1C9; -.
DR   IntAct; Q8R1C9; 1.
DR   MINT; Q8R1C9; -.
DR   iPTMnet; Q8R1C9; -.
DR   PhosphoSitePlus; Q8R1C9; -.
DR   PaxDb; Q8R1C9; -.
DR   PRIDE; Q8R1C9; -.
DR   ProteomicsDB; 296366; -.
DR   Antibodypedia; 1613; 192 antibodies from 23 providers.
DR   DNASU; 225372; -.
DR   Ensembl; ENSMUST00000001415; ENSMUSP00000001415; ENSMUSG00000117679.
DR   GeneID; 225372; -.
DR   KEGG; mmu:225372; -.
DR   UCSC; uc033hgf.1; mouse.
DR   CTD; 10307; -.
DR   MGI; MGI:108404; Apbb3.
DR   VEuPathDB; HostDB:ENSMUSG00000117679; -.
DR   GeneTree; ENSGT00390000000002; -.
DR   HOGENOM; CLU_021196_0_0_1; -.
DR   InParanoid; Q8R1C9; -.
DR   OMA; LYMGILP; -.
DR   OrthoDB; 437627at2759; -.
DR   PhylomeDB; Q8R1C9; -.
DR   TreeFam; TF314331; -.
DR   BioGRID-ORCS; 225372; 0 hits in 42 CRISPR screens.
DR   ChiTaRS; Apbb3; mouse.
DR   PRO; PR:Q8R1C9; -.
DR   Proteomes; UP000000589; Chromosome 18.
DR   RNAct; Q8R1C9; protein.
DR   Bgee; ENSMUSG00000117679; Expressed in retinal neural layer and 186 other tissues.
DR   ExpressionAtlas; Q8R1C9; baseline and differential.
DR   Genevisible; Q8R1C9; MM.
DR   GO; GO:0015629; C:actin cytoskeleton; ISO:MGI.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; ISO:MGI.
DR   GO; GO:0016020; C:membrane; ISO:MGI.
DR   GO; GO:0005634; C:nucleus; ISO:MGI.
DR   GO; GO:0001540; F:amyloid-beta binding; ISO:MGI.
DR   GO; GO:0050750; F:low-density lipoprotein particle receptor binding; ISO:MGI.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; TAS:MGI.
DR   GO; GO:1901988; P:negative regulation of cell cycle phase transition; ISO:MGI.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:MGI.
DR   GO; GO:0050714; P:positive regulation of protein secretion; ISO:MGI.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   CDD; cd00201; WW; 1.
DR   Gene3D; 2.30.29.30; -; 2.
DR   InterPro; IPR039576; APBB1/2/3.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR006020; PTB/PI_dom.
DR   InterPro; IPR001202; WW_dom.
DR   InterPro; IPR036020; WW_dom_sf.
DR   PANTHER; PTHR14058; PTHR14058; 1.
DR   Pfam; PF00640; PID; 1.
DR   SMART; SM00462; PTB; 2.
DR   SMART; SM00456; WW; 1.
DR   SUPFAM; SSF51045; SSF51045; 1.
DR   PROSITE; PS01179; PID; 2.
DR   PROSITE; PS01159; WW_DOMAIN_1; 1.
DR   PROSITE; PS50020; WW_DOMAIN_2; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; Repeat.
FT   CHAIN           1..486
FT                   /note="Amyloid-beta A4 precursor protein-binding family B
FT                   member 3"
FT                   /id="PRO_0000076055"
FT   DOMAIN          29..61
FT                   /note="WW"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00224"
FT   DOMAIN          113..280
FT                   /note="PID 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00148"
FT   DOMAIN          285..440
FT                   /note="PID 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00148"
FT   REGION          438..460
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   486 AA;  52638 MW;  BEF1F66CAF10A139 CRC64;
     MLGKDYMLAI ILVNCDDDLW GDQNLEGETG LPPGWRKIRD AAGTYYWHVP SGSTQWQRPT
     WELPGAEDPG RGTEGIWELR PPKGRSFSSL DSSLNRSNSL TWYSEDSYVR SLEPGAKCFA
     VRSLGWVEVP EEDLAPGKSS IAVNNCIQQL AQTRNRSQPH DGTWGEGQNM LMILKKDAMS
     LLNPLDHSLI HCQPLVHIRV WGVGSSKGRD RDFAFVAGDK DSCMLKCHVF HCDVPAKAIA
     SALQGLCAQI LSERVGVSGE AACCSPDPIS PEDLPRQVEL LDAVSQAAQK YEALYMGILP
     VTKAMGMDVL NEAIGTLTAR GDRKTWVPAM LSVSDSLMTA HAIQAEAGAE EEPLWQCPVR
     LVTFIGVGRD PHTFGLIADL GCQSFQCAAF WCEPHAGGLS EAVQAACMVQ YQKCLVASAA
     RGKAWGAQAR ARLRLKRTSS MDSPGGPLPP PLLKGGAGGA GAAPRKRGVF SFLDAFRLKP
     SLLHMS