IAN4_ARATH
ID IAN4_ARATH Reviewed; 326 AA.
AC Q9C8U7;
DT 02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Immune-associated nucleotide-binding protein 4 {ECO:0000303|PubMed:17723251};
DE Short=AtIAN4 {ECO:0000303|PubMed:17723251};
DE AltName: Full=AIG1-like protein {ECO:0000305};
GN Name=IAN4 {ECO:0000303|PubMed:17723251};
GN OrderedLocusNames=At1g33900 {ECO:0000312|Araport:AT1G33900};
GN ORFNames=T3M13.8 {ECO:0000312|EMBL:AAG52208.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=17723251; DOI=10.1016/j.jplph.2007.06.002;
RA Liu C., Wang T., Zhang W., Li X.;
RT "Computational identification and analysis of immune-associated nucleotide
RT gene family in Arabidopsis thaliana.";
RL J. Plant Physiol. 165:777-787(2008).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. {ECO:0000305};
CC Name=1;
CC IsoId=Q9C8U7-1; Sequence=Displayed;
CC -!- TISSUE SPECIFICITY: Expressed in radicles of the germinating seeds.
CC {ECO:0000305|PubMed:17723251}.
CC -!- DEVELOPMENTAL STAGE: Expressed at the early flowering stage and at the
CC late stage of silique development. {ECO:0000305|PubMed:17723251}.
CC -!- INDUCTION: Up-regulated by brassinolides. Down-regulated by 2-
CC aminoethoxyvinylglycine (AVG), high CO(2), isoxaben, and propiconazole
CC treatments. {ECO:0000305|PubMed:17723251}.
CC -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family.
CC IAN subfamily. {ECO:0000305}.
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DR EMBL; AC022288; AAG52208.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE31638.1; -; Genomic_DNA.
DR PIR; G86462; G86462.
DR RefSeq; NP_174652.1; NM_103112.1. [Q9C8U7-1]
DR AlphaFoldDB; Q9C8U7; -.
DR SMR; Q9C8U7; -.
DR PaxDb; Q9C8U7; -.
DR PRIDE; Q9C8U7; -.
DR ProteomicsDB; 232166; -. [Q9C8U7-1]
DR EnsemblPlants; AT1G33900.1; AT1G33900.1; AT1G33900. [Q9C8U7-1]
DR GeneID; 840287; -.
DR Gramene; AT1G33900.1; AT1G33900.1; AT1G33900. [Q9C8U7-1]
DR KEGG; ath:AT1G33900; -.
DR Araport; AT1G33900; -.
DR TAIR; locus:2203797; AT1G33900.
DR eggNOG; ENOG502R7PE; Eukaryota.
DR HOGENOM; CLU_010468_0_1_1; -.
DR InParanoid; Q9C8U7; -.
DR OMA; CKEIARC; -.
DR PhylomeDB; Q9C8U7; -.
DR PRO; PR:Q9C8U7; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9C8U7; baseline and differential.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:TAIR.
DR GO; GO:0005886; C:plasma membrane; IDA:TAIR.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0034605; P:cellular response to heat; IGI:TAIR.
DR GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IGI:TAIR.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR006703; G_AIG1.
DR InterPro; IPR045058; GIMA/IAN/Toc.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10903; PTHR10903; 1.
DR Pfam; PF04548; AIG1; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51720; G_AIG1; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Coiled coil; GTP-binding; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..326
FT /note="Immune-associated nucleotide-binding protein 4"
FT /id="PRO_0000438028"
FT DOMAIN 17..225
FT /note="AIG1-type G"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01057"
FT REGION 26..33
FT /note="G1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01057"
FT REGION 53..57
FT /note="G2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01057"
FT REGION 75..78
FT /note="G3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01057"
FT REGION 145..148
FT /note="G4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01057"
FT REGION 184..186
FT /note="G5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01057"
FT COILED 217..241
FT /evidence="ECO:0000255"
FT BINDING 26..34
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:Q8NHV1"
FT BINDING 47
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:Q8NHV1"
FT BINDING 185
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:Q8NHV1"
SQ SEQUENCE 326 AA; 36397 MW; E45CA81B8DD5D77C CRC64;
MAGLEDTTDL RLPSASEPIK NIVLVGRTGN GKSATGNSLI GKQVFRSETR ATGVTMKCET
CVAVTPCGTG INVIDTPGLF DLSVSAEYLS QEIINCLVLA EDGLHAVVLV LSVRTRISQE
EEATLNTLQV IFGSQIIDYL VVLFTGGDEL EANNMTLDDY LSKGCPEFLK TVLRLCGGRR
ILFDNRTTDE GKKVKQVQEL LAHVAAIEKS TSGIPFTDEM HRKIQKEAET LREQQKEVES
KDLAAAEIEK WKKHYQTEHD KNMNMMAEML GNRLREDSER QEKMLLALRD NLEISQRQNK
LNELTDNEPD LIHCGVSLRR MPCNML
