ID   APBB3_RAT               Reviewed;         504 AA.
AC   O35827;
DT   11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 118.
DE   RecName: Full=Amyloid-beta A4 precursor protein-binding family B member 3;
DE   AltName: Full=Protein Fe65-like 2;
DE            Short=Fe65L2;
GN   Name=Apbb3 {ECO:0000312|RGD:620853};
GN   Synonyms=Fe65l2 {ECO:0000312|RGD:620853};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH APP, AND TISSUE SPECIFICITY.
RX   PubMed=9461550; DOI=10.1042/bj3300513;
RA   Duilio A., Faraonio R., Minopoli G., Zambrano N., Russo T.;
RT   "Fe65L2: a new member of the Fe65 protein family interacting with the
RT   intracellular domain of the Alzheimer's beta-amyloid precursor protein.";
RL   Biochem. J. 330:513-519(1998).
CC   -!- FUNCTION: May modulate the internalization of amyloid-beta precursor
CC       protein.
CC   -!- SUBUNIT: Interacts with APP (via intracellular domain)
CC       (PubMed:9461550). Interacts with APLP1 and APLP2 (via intracellular
CC       domain) (By similarity). {ECO:0000250|UniProtKB:O95704,
CC       ECO:0000269|PubMed:9461550}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O95704}. Nucleus
CC       {ECO:0000250|UniProtKB:O95704}.
CC   -!- TISSUE SPECIFICITY: Expressed predominantly in brain and testis.
CC       {ECO:0000269|PubMed:9461550}.
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DR   EMBL; Y13413; CAA73837.1; -; mRNA.
DR   RefSeq; NP_446409.1; NM_053957.1.
DR   AlphaFoldDB; O35827; -.
DR   SMR; O35827; -.
DR   IntAct; O35827; 2.
DR   STRING; 10116.ENSRNOP00000024313; -.
DR   PaxDb; O35827; -.
DR   GeneID; 117026; -.
DR   KEGG; rno:117026; -.
DR   UCSC; RGD:620853; rat.
DR   CTD; 10307; -.
DR   RGD; 620853; Apbb3.
DR   eggNOG; ENOG502QR5N; Eukaryota.
DR   InParanoid; O35827; -.
DR   OrthoDB; 437627at2759; -.
DR   PhylomeDB; O35827; -.
DR   PRO; PR:O35827; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; ISO:RGD.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0001540; F:amyloid-beta binding; IPI:RGD.
DR   GO; GO:0050750; F:low-density lipoprotein particle receptor binding; ISO:RGD.
DR   GO; GO:1901988; P:negative regulation of cell cycle phase transition; IDA:UniProtKB.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:UniProtKB.
DR   GO; GO:0050714; P:positive regulation of protein secretion; ISO:RGD.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   CDD; cd00201; WW; 1.
DR   Gene3D; 2.30.29.30; -; 2.
DR   InterPro; IPR039576; APBB1/2/3.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR006020; PTB/PI_dom.
DR   InterPro; IPR001202; WW_dom.
DR   InterPro; IPR036020; WW_dom_sf.
DR   PANTHER; PTHR14058; PTHR14058; 1.
DR   Pfam; PF00640; PID; 1.
DR   SMART; SM00462; PTB; 2.
DR   SMART; SM00456; WW; 1.
DR   SUPFAM; SSF51045; SSF51045; 1.
DR   PROSITE; PS01179; PID; 2.
DR   PROSITE; PS01159; WW_DOMAIN_1; 1.
DR   PROSITE; PS50020; WW_DOMAIN_2; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Nucleus; Reference proteome; Repeat.
FT   CHAIN           1..504
FT                   /note="Amyloid-beta A4 precursor protein-binding family B
FT                   member 3"
FT                   /id="PRO_0000076056"
FT   DOMAIN          29..61
FT                   /note="WW"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00224"
FT   DOMAIN          111..278
FT                   /note="PID 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00148"
FT   DOMAIN          283..438
FT                   /note="PID 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00148"
SQ   SEQUENCE   504 AA;  54907 MW;  A49CA9E99BDB3A3A CRC64;
     MLGKDYMLAI ILVNCDDDLW GDQNLEGETG LPPGWRKIRD AAGTYYWHVP SGSTQWQRPT
     WELAEDPGTG KEGIWELRPP KGRSFSSLDS SLNRSNSLTW YNEDSYVRSL EPGAKCFAVR
     SLGWVEVPEE DLAPGKSSIA VNNCIQQLAQ ARNRSQPHDG AWGEGQNMLM VLKKDAMSLL
     NPLDHSLIHC QPLVHIRVWG VGSSKGRDRD FAFVAGDKDS CMLKCHVFRC DVPAKAIASR
     LQGLCAQILS ERVGLSGEAA CCSPDPISPE DFPRQVELLD AVSQAAQKYE ALYMGILPVT
     KAMGMDVLNE AIGTLTGRGD RKTWVPAMLS VSDSLMTAHP IQAEAGAEEE PLWQCPVRLV
     TFIGVGHDPH TFGLIADLGC QSFQCAAFWC QPHAGGLSEA VQAACMVQYQ KCLVASAARG
     KAWGAQARAR LRLKRTSSMD SPGGPLPPPL LKGGVGGAGA APRKRGVFSF LDAFRLKPLF
     SICPKLILEG WGKRLYTLPV PRVL