IAN8_ARATH
ID IAN8_ARATH Reviewed; 353 AA.
AC P54120;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Immune-associated nucleotide-binding protein 8 {ECO:0000303|PubMed:17723251};
DE Short=AtIAN8 {ECO:0000303|PubMed:17723251};
DE AltName: Full=Protein AIG1 {ECO:0000303|PubMed:8742710};
GN Name=IAN8 {ECO:0000303|PubMed:17723251};
GN Synonyms=AIG1 {ECO:0000303|PubMed:8742710};
GN OrderedLocusNames=At1g33960 {ECO:0000312|Araport:AT1G33960};
GN ORFNames=T3M13.2 {ECO:0000312|EMBL:AAG52213.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND INDUCTION.
RC STRAIN=cv. Columbia;
RX PubMed=8742710; DOI=10.2307/3870267;
RA Reuber T.L., Ausubel F.M.;
RT "Isolation of Arabidopsis genes that differentiate between resistance
RT responses mediated by the RPS2 and RPM1 disease resistance genes.";
RL Plant Cell 8:241-249(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=17723251; DOI=10.1016/j.jplph.2007.06.002;
RA Liu C., Wang T., Zhang W., Li X.;
RT "Computational identification and analysis of immune-associated nucleotide
RT gene family in Arabidopsis thaliana.";
RL J. Plant Physiol. 165:777-787(2008).
CC -!- TISSUE SPECIFICITY: Mainly expressed in leaves.
CC {ECO:0000305|PubMed:17723251}.
CC -!- DEVELOPMENTAL STAGE: Expressed at the flowering stage.
CC {ECO:0000305|PubMed:17723251}.
CC -!- INDUCTION: Up-regulated early after infection with P.syringae carrying
CC avrRpt2 (PubMed:8742710). Up-regulated by brassinolide, cold treatment,
CC syringolin, P.infestans infection and, at a lower level, by salicylic
CC acid (PubMed:17723251). Down-regulated by 2-aminoethoxyvinylglycine
CC (AVG), high CO(2), isoxaben, and propiconazole treatments
CC (PubMed:17723251). {ECO:0000269|PubMed:8742710,
CC ECO:0000305|PubMed:17723251}.
CC -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family.
CC IAN subfamily. {ECO:0000305}.
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DR EMBL; U40856; AAC49282.1; -; mRNA.
DR EMBL; AC022288; AAG52213.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE31647.1; -; Genomic_DNA.
DR RefSeq; NP_174658.1; NM_103118.4.
DR AlphaFoldDB; P54120; -.
DR SMR; P54120; -.
DR STRING; 3702.AT1G33960.1; -.
DR PaxDb; P54120; -.
DR PRIDE; P54120; -.
DR ProteomicsDB; 232170; -.
DR EnsemblPlants; AT1G33960.1; AT1G33960.1; AT1G33960.
DR GeneID; 840293; -.
DR Gramene; AT1G33960.1; AT1G33960.1; AT1G33960.
DR KEGG; ath:AT1G33960; -.
DR Araport; AT1G33960; -.
DR TAIR; locus:2203807; AT1G33960.
DR eggNOG; ENOG502R7PE; Eukaryota.
DR HOGENOM; CLU_010468_0_1_1; -.
DR InParanoid; P54120; -.
DR PhylomeDB; P54120; -.
DR PRO; PR:P54120; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; P54120; baseline and differential.
DR Genevisible; P54120; AT.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0009617; P:response to bacterium; IEP:TAIR.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR006703; G_AIG1.
DR InterPro; IPR045058; GIMA/IAN/Toc.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10903; PTHR10903; 1.
DR Pfam; PF04548; AIG1; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51720; G_AIG1; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; GTP-binding; Nucleotide-binding; Reference proteome.
FT CHAIN 1..353
FT /note="Immune-associated nucleotide-binding protein 8"
FT /id="PRO_0000190995"
FT DOMAIN 40..248
FT /note="AIG1-type G"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01057"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 49..56
FT /note="G1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01057"
FT REGION 76..80
FT /note="G2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01057"
FT REGION 98..101
FT /note="G3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01057"
FT REGION 168..171
FT /note="G4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01057"
FT REGION 207..209
FT /note="G5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01057"
FT COILED 244..291
FT /evidence="ECO:0000255"
FT COMPBIAS 9..37
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 49..57
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:Q8NHV1"
FT BINDING 70
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:Q8NHV1"
FT BINDING 208
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:Q8NHV1"
SQ SEQUENCE 353 AA; 40070 MW; 99C6787D84718A2E CRC64;
MANDQKNSES FPAKEDHKKD DAAAPAEVDH KDEFSASQPH PVENIVLVGR TGNGKSATGN
SIVRSKVFKS KTKSSGVTME CHAVKAVTPE GPILNVIDTP GLFDLSVSAE FIGKEIVKCL
TLADGGLHAV LLVLSVRTRI SQEEEMVLST LQVLFGSKIV DYLIVVFTGG DVLEDDGMTL
EDYLGDNMPD FLKRVLILCG QRMILFDNKT KDDEKKTKQV HELLKLIDLV RKQNNNIPYT
DEMYHMIKEE NERHKKEQEE LESKGHSEEQ LAALMKELQI MNERNLKAMA EMMEKNMKIA
MEAQEKLFEQ REKAQEMSYQ QKMEMQEKLK QMEGRMRAEM EAQMLSRQQC SIL
