ID   IAP1_NPVAC              Reviewed;         286 AA.
AC   P41435;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Apoptosis inhibitor 1;
DE   AltName: Full=IAP-1;
GN   Name=IAP1;
OS   Autographa californica nuclear polyhedrosis virus (AcMNPV).
OC   Viruses; Naldaviricetes; Lefavirales; Baculoviridae; Alphabaculovirus.
OX   NCBI_TaxID=46015;
OH   NCBI_TaxID=7088; Lepidoptera (butterflies and moths).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C6;
RX   PubMed=8030224; DOI=10.1006/viro.1994.1380;
RA   Ayres M.D., Howard S.C., Kuzio J., Lopez-Ferber M., Possee R.D.;
RT   "The complete DNA sequence of Autographa californica nuclear polyhedrosis
RT   virus.";
RL   Virology 202:586-605(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=E2;
RX   PubMed=1333113; DOI=10.1016/0042-6822(92)90281-s;
RA   Braunagel S.C., Daniel K.D., Reilly L.M., Guarino L.A., Hong T.,
RA   Summers M.D.;
RT   "Sequence, genomic organization of the EcoRI-A fragment of Autographa
RT   californica nuclear polyhedrosis virus, and identification of a viral-
RT   encoded protein resembling the outer capsid protein VP8 of rotavirus.";
RL   Virology 191:1003-1008(1992).
RN   [3]
RP   FUNCTION.
RX   PubMed=19727595; DOI=10.1007/s11427-009-0105-5;
RA   Zeng X., Nan F., Liang C., Song J., Wang Q., Vlak J.M., Chen X.;
RT   "Functional analysis of the Autographa californica nucleopolyhedrovirus
RT   IAP1 and IAP2.";
RL   Sci. China, Ser. C, Life Sci. 52:761-770(2009).
RN   [4]
RP   FUNCTION.
RX   PubMed=21795471; DOI=10.1099/vir.0.033332-0;
RA   Ikeda M., Yamada H., Ito H., Kobayashi M.;
RT   "Baculovirus IAP1 induces caspase-dependent apoptosis in insect cells.";
RL   J. Gen. Virol. 92:2654-2663(2011).
CC   -!- FUNCTION: Acts by blocking cellular apoptosis early in infection.
CC       Later, stimulates caspase-3-like protease activity and induces
CC       apoptosis, probably to favor the release of occluded virions.
CC       {ECO:0000269|PubMed:19727595, ECO:0000269|PubMed:21795471}.
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DR   EMBL; L22858; AAA66657.1; -; Genomic_DNA.
DR   EMBL; M96361; AAA66796.1; -; Genomic_DNA.
DR   PIR; D36828; D36828.
DR   RefSeq; NP_054056.1; NC_001623.1.
DR   PRIDE; P41435; -.
DR   GeneID; 1403859; -.
DR   KEGG; vg:1403859; -.
DR   Proteomes; UP000008292; Genome.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0039526; P:modulation by virus of host apoptotic process; IEA:UniProtKB-KW.
DR   CDD; cd00022; BIR; 2.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR001370; BIR_rpt.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   Pfam; PF00653; BIR; 2.
DR   SMART; SM00238; BIR; 2.
DR   SMART; SM00184; RING; 1.
DR   PROSITE; PS01282; BIR_REPEAT_1; 2.
DR   PROSITE; PS50143; BIR_REPEAT_2; 2.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   4: Predicted;
KW   Apoptosis; Host-virus interaction; Metal-binding;
KW   Modulation of host cell apoptosis by virus; Reference proteome; Repeat;
KW   Zinc; Zinc-finger.
FT   CHAIN           1..286
FT                   /note="Apoptosis inhibitor 1"
FT                   /id="PRO_0000122369"
FT   REPEAT          29..96
FT                   /note="BIR 1"
FT   REPEAT          131..199
FT                   /note="BIR 2"
FT   ZN_FING         238..274
FT                   /note="RING-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT   BINDING         169
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00029"
FT   BINDING         172
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00029"
FT   BINDING         189
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00029"
FT   BINDING         196
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00029"
SQ   SEQUENCE   286 AA;  33320 MW;  FFEE505A35EF1BEA CRC64;
     MNEDTPPFYF ISVCDNFRDN TAEHVFDMLI ERHSSFENYP IENTAFINSL IVNGFKYNQV
     DDHVVCEYCE AEIKNWSEDE CIEYAHVTLS PYCAYANKIA ERESFGDNIT INAVLVKEGK
     PKCVYRCMSN LQSRMDTFVN FWPAALRDMI TNIAEAGLFY TGRGDETVCF FCDCCVRDWH
     TNEDTWQRHA AENPQCYFVL SVKGKEFCQN SITVTHVDKR DDDNLNENAD DIEEKYECKV
     CLERQRDAVL MPCRHFCVCV QCYFGLDQKC PTCRQDVTDF IKIFVV