ID   IAP1_NPVOP              Reviewed;         275 AA.
AC   O10296;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Apoptosis inhibitor 1;
DE   AltName: Full=IAP-1;
GN   Name=IAP1; ORFNames=ORF41;
OS   Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV).
OC   Viruses; Naldaviricetes; Lefavirales; Baculoviridae; Alphabaculovirus.
OX   NCBI_TaxID=262177;
OH   NCBI_TaxID=33414; Orgyia pseudotsugata (Douglas-fir tussock moth).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=9126251; DOI=10.1006/viro.1997.8448;
RA   Ahrens C.H., Russell R.R., Funk C.J., Evans J., Harwood S., Rohrmann G.F.;
RT   "The sequence of the Orgyia pseudotsugata multinucleocapsid nuclear
RT   polyhedrosis virus genome.";
RL   Virology 229:381-399(1997).
CC   -!- FUNCTION: Acts by blocking cellular apoptosis rather than by preventing
CC       viral stimulation of apoptosis.
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DR   EMBL; U75930; AAC59040.1; -; Genomic_DNA.
DR   RefSeq; NP_046197.1; NC_001875.2.
DR   GeneID; 912079; -.
DR   KEGG; vg:912079; -.
DR   Proteomes; UP000009248; Genome.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd00022; BIR; 2.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR001370; BIR_rpt.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   Pfam; PF00653; BIR; 2.
DR   SMART; SM00238; BIR; 2.
DR   SMART; SM00184; RING; 1.
DR   PROSITE; PS01282; BIR_REPEAT_1; 2.
DR   PROSITE; PS50143; BIR_REPEAT_2; 2.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   4: Predicted;
KW   Apoptosis; Metal-binding; Repeat; Zinc; Zinc-finger.
FT   CHAIN           1..275
FT                   /note="Apoptosis inhibitor 1"
FT                   /id="PRO_0000122370"
FT   REPEAT          24..91
FT                   /note="BIR 1"
FT   REPEAT          126..193
FT                   /note="BIR 2"
FT   ZN_FING         227..263
FT                   /note="RING-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT   BINDING         163
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00029"
FT   BINDING         166
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00029"
FT   BINDING         183
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00029"
FT   BINDING         190
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00029"
SQ   SEQUENCE   275 AA;  30956 MW;  A98F52F793A5B966 CRC64;
     MSAPLYVINV CDHETSAERV FGMLIERHNS FEDYPIDNDA FVNSLIVNGF RYTHVDDAVV
     CEYCGVVIKN WRENDVVEFV HATLSPYCVY ANKIAQNEQF AEDISTDAVV VSPGKPRCVY
     NRLAHPSARR ATFDHWPAAL NALTHDIAEA GMFHTMLGDE TACFFCDCRV RDWLPGDDPW
     QRHALANPQC YFVVCVKGDG FCNSERRAET APGEPAPAFA GSEALECKVC LERQRDAVLL
     PCRHFCVCMQ CYFALDGKCP TCRQDVADFI KIFVT