ID   IAP2_NPVAC              Reviewed;         249 AA.
AC   P41454;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Probable apoptosis inhibitor 2;
DE   AltName: Full=IAP-2;
GN   Name=IAP2;
OS   Autographa californica nuclear polyhedrosis virus (AcMNPV).
OC   Viruses; Naldaviricetes; Lefavirales; Baculoviridae; Alphabaculovirus.
OX   NCBI_TaxID=46015;
OH   NCBI_TaxID=7088; Lepidoptera (butterflies and moths).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C6;
RX   PubMed=8030224; DOI=10.1006/viro.1994.1380;
RA   Ayres M.D., Howard S.C., Kuzio J., Lopez-Ferber M., Possee R.D.;
RT   "The complete DNA sequence of Autographa californica nuclear polyhedrosis
RT   virus.";
RL   Virology 202:586-605(1994).
RN   [2]
RP   FUNCTION.
RX   PubMed=19727595; DOI=10.1007/s11427-009-0105-5;
RA   Zeng X., Nan F., Liang C., Song J., Wang Q., Vlak J.M., Chen X.;
RT   "Functional analysis of the Autographa californica nucleopolyhedrovirus
RT   IAP1 and IAP2.";
RL   Sci. China, Ser. C, Life Sci. 52:761-770(2009).
CC   -!- FUNCTION: Plays a role in the inhibition of host apoptosis.
CC       {ECO:0000269|PubMed:19727595}.
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DR   EMBL; L22858; AAA66701.1; -; Genomic_DNA.
DR   PIR; H72858; H72858.
DR   RefSeq; NP_054101.1; NC_001623.1.
DR   GeneID; 1403904; -.
DR   KEGG; vg:1403904; -.
DR   Proteomes; UP000008292; Genome.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0039526; P:modulation by virus of host apoptotic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR001370; BIR_rpt.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PROSITE; PS50143; BIR_REPEAT_2; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   4: Predicted;
KW   Apoptosis; Host-virus interaction; Metal-binding;
KW   Modulation of host cell apoptosis by virus; Reference proteome; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..249
FT                   /note="Probable apoptosis inhibitor 2"
FT                   /id="PRO_0000122385"
FT   REPEAT          85..152
FT                   /note="BIR"
FT   ZN_FING         202..237
FT                   /note="RING-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT   BINDING         125
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00029"
FT   BINDING         128
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00029"
FT   BINDING         144
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00029"
FT   BINDING         148
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00029"
SQ   SEQUENCE   249 AA;  28621 MW;  4DE2825A792EE520 CRC64;
     MNLMQFNFLI LSTDGRFRTM ANMSLDNEYK LELAKTGLFS HNNLIKCIGC RTILDKINAK
     QIKRHTYSNY CISSTNALMF NESMRKKSFT SFKSSRRQFA SQSVVVDMLA RRGFYYFGKA
     GHLRCSGCHI VFKYKSVDDA QRRHKQNCKF LNAIEDYSVN EQFGKLDVAE KEILAADLIP
     PRLSVKPSAP PAEPLTQQVS ECKVCFDREK SVCFMPCRHL AVCTECSRRC KRCCVCNAKI
     MQRIETLPQ