ID   APBC_AQUAE              Reviewed;         364 AA.
AC   O66946;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=Iron-sulfur cluster carrier protein {ECO:0000255|HAMAP-Rule:MF_02040};
GN   Name=mrp; OrderedLocusNames=aq_737;
OS   Aquifex aeolicus (strain VF5).
OC   Bacteria; Aquificae; Aquificales; Aquificaceae; Aquifex.
OX   NCBI_TaxID=224324;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VF5;
RX   PubMed=9537320; DOI=10.1038/32831;
RA   Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L.,
RA   Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R.,
RA   Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.;
RT   "The complete genome of the hyperthermophilic bacterium Aquifex aeolicus.";
RL   Nature 392:353-358(1998).
CC   -!- FUNCTION: Binds and transfers iron-sulfur (Fe-S) clusters to target
CC       apoproteins. Can hydrolyze ATP. {ECO:0000255|HAMAP-Rule:MF_02040}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_02040}.
CC   -!- SIMILARITY: Belongs to the Mrp/NBP35 ATP-binding proteins family.
CC       {ECO:0000255|HAMAP-Rule:MF_02040}.
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DR   EMBL; AE000657; AAC06915.1; -; Genomic_DNA.
DR   PIR; G70364; G70364.
DR   RefSeq; NP_213507.1; NC_000918.1.
DR   RefSeq; WP_010880445.1; NC_000918.1.
DR   AlphaFoldDB; O66946; -.
DR   SMR; O66946; -.
DR   STRING; 224324.aq_737; -.
DR   EnsemblBacteria; AAC06915; AAC06915; aq_737.
DR   KEGG; aae:aq_737; -.
DR   PATRIC; fig|224324.8.peg.590; -.
DR   eggNOG; COG0489; Bacteria.
DR   HOGENOM; CLU_024839_0_0_0; -.
DR   InParanoid; O66946; -.
DR   OMA; NMAYFTP; -.
DR   OrthoDB; 1413173at2; -.
DR   Proteomes; UP000000798; Chromosome.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0140663; F:ATP-dependent FeS chaperone activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_02040; Mrp_NBP35; 1.
DR   InterPro; IPR019591; Mrp/NBP35_ATP-bd.
DR   InterPro; IPR000808; Mrp_CS.
DR   InterPro; IPR044304; NUBPL-like.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR033756; YlxH/NBP35.
DR   PANTHER; PTHR42961; PTHR42961; 1.
DR   Pfam; PF10609; ParA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS01215; MRP; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Hydrolase; Iron; Iron-sulfur; Metal-binding;
KW   Nucleotide-binding; Reference proteome.
FT   CHAIN           1..364
FT                   /note="Iron-sulfur cluster carrier protein"
FT                   /id="PRO_0000184928"
FT   REGION          83..102
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         120..127
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02040"
SQ   SEQUENCE   364 AA;  39492 MW;  320AF95C191A272A CRC64;
     MAVQDVIEAL KKETLEDVGI NQNLAQLVKD IKMVGNVLTI VFEPPKQGLE DIIRAKVIDA
     LGNLPEVQKI DVKFVKPQAQ IPVKQQAPQQ QQTPPPQTQQ PMFTRKKVPG VKHIIAVGSG
     KGGVGKSTVA ANLAVALSQL GYKVGLLDAD VYGPSVPTLF GLKGERVTVD QFQRIIPVEK
     YGLKILSIGF MLPSEDTPII WRGPMLMKAL TEFLFSTKWG NLDFLVMDLP PGTGDVQITL
     AQNVELTGAV VVTTPQDVAL ADVKKAVSMF REVNIPVLGV IENMAYFICP SDKQKYYIFG
     KGKVAEFANA YGLKILGSIP IDPEVAEKSD KGEPIVISHP DSEVAKAFLS IAKVLSQVVE
     SKVN