ID   IAPL_ASFC1              Reviewed;         224 AA.
AC   P68764; O12407;
DT   21-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 41.
DE   RecName: Full=IAP-like protein p27;
GN   Name=p27; ORFNames=4CL;
OS   African swine fever virus (isolate Tick/South Africa/Crocodile Cr1/1996)
OS   (ASFV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Asfuvirales; Asfarviridae; Asfivirus.
OX   NCBI_TaxID=82810;
OH   NCBI_TaxID=6937; Ornithodoros (relapsing fever ticks).
OH   NCBI_TaxID=85517; Phacochoerus aethiopicus (Warthog).
OH   NCBI_TaxID=41426; Phacochoerus africanus (Warthog).
OH   NCBI_TaxID=273792; Potamochoerus larvatus (Bushpig).
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9143281; DOI=10.1006/viro.1997.8481;
RA   Neilan J.G., Lu Z., Kutish G.F., Zsak L., Burrage T.G., Borca M.V.,
RA   Carrillo C., Rock D.L.;
RT   "A BIR motif containing gene of African swine fever virus, 4CL, is
RT   nonessential for growth in vitro and viral virulence.";
RL   Virology 230:252-264(1997).
CC   -!- FUNCTION: Not essential for growth or virulence. Does not have
CC       antiapoptotic function.
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DR   EMBL; U91731; AAB58386.1; -; Genomic_DNA.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd00022; BIR; 1.
DR   InterPro; IPR010549; ASFV_p27_C.
DR   InterPro; IPR001370; BIR_rpt.
DR   Pfam; PF06556; ASFV_p27; 1.
DR   Pfam; PF00653; BIR; 1.
DR   SMART; SM00238; BIR; 1.
DR   PROSITE; PS01282; BIR_REPEAT_1; 1.
DR   PROSITE; PS50143; BIR_REPEAT_2; 1.
PE   4: Predicted;
KW   Metal-binding; Zinc.
FT   CHAIN           1..224
FT                   /note="IAP-like protein p27"
FT                   /id="PRO_0000122374"
FT   REPEAT          29..92
FT                   /note="BIR"
FT   BINDING         62
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00029"
FT   BINDING         65
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00029"
FT   BINDING         82
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00029"
FT   BINDING         89
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00029"
SQ   SEQUENCE   224 AA;  26558 MW;  8E579C948F132F05 CRC64;
     MFPKINTIDP YISLRLFEVK PKYVGYSSVD ARNQSFAIHD IKNYEKFSNA GLFYTSPTEI
     TCYCCGMKFC NWLYEKHPLQ VHGFWSRNCG FMRATLGIIG LKKMIDSYND YYNNEVFVKH
     KNRVYTHKKL EDMGFSKPFM QFILANAFIP PYRKYIHKII LNDRYFTFKF AAHLLSFHKV
     NLDNQTTYCM TCGIEPIKKD ENFCNACKTL NYKHYKTLNF SVKL