ID   IAPP_CRIGR              Reviewed;          37 AA.
AC   P19890;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Islet amyloid polypeptide;
DE   AltName: Full=Amylin;
GN   Name=IAPP;
OS   Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Cricetulus.
OX   NCBI_TaxID=10029;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND SYNTHESIS OF 20-29.
RX   PubMed=2666169; DOI=10.1016/0014-5793(89)81467-x;
RA   Betsholtz C., Christmansson L., Engstroem U., Rorsman F., Svensson V.,
RA   Johnson K.H., Westermark P.;
RT   "Sequence divergence in a specific region of islet amyloid polypeptide
RT   (IAPP) explains differences in islet amyloid formation between species.";
RL   FEBS Lett. 251:261-264(1989).
CC   -!- FUNCTION: Selectively inhibits insulin-stimulated glucose utilization
CC       and glycogen deposition in muscle, while not affecting adipocyte
CC       glucose metabolism. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with IDE and INS. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- DOMAIN: The mature protein is largely unstructured in the absence of a
CC       cognate ligand, but contrary to the human protein, it does not easily
CC       form fibrillar aggregates. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the calcitonin family. {ECO:0000305}.
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DR   PIR; S05037; S05037.
DR   AlphaFoldDB; P19890; -.
DR   BMRB; P19890; -.
DR   SMR; P19890; -.
DR   STRING; 10029.XP_007630956.1; -.
DR   eggNOG; ENOG502S4AQ; Eukaryota.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR021117; Calcitonin-like.
DR   InterPro; IPR021116; Calcitonin/adrenomedullin.
DR   InterPro; IPR018360; Calcitonin_CS.
DR   InterPro; IPR001693; Calcitonin_peptide-like.
DR   InterPro; IPR000443; IAPP.
DR   PANTHER; PTHR10505; PTHR10505; 1.
DR   PANTHER; PTHR10505:SF4; PTHR10505:SF4; 1.
DR   Pfam; PF00214; Calc_CGRP_IAPP; 1.
DR   PRINTS; PR00818; ISLETAMYLOID.
DR   SMART; SM00113; CALCITONIN; 1.
DR   PROSITE; PS00258; CALCITONIN; 1.
PE   3: Inferred from homology;
KW   Amidation; Amyloid; Disulfide bond; Hormone; Secreted.
FT   PEPTIDE         1..37
FT                   /note="Islet amyloid polypeptide"
FT                   /id="PRO_0000044675"
FT   MOD_RES         37
FT                   /note="Tyrosine amide"
FT                   /evidence="ECO:0000250"
FT   DISULFID        2..7
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   37 AA;  3921 MW;  FE433D9905EBF82E CRC64;
     KCNTATCATQ RLANFLVHSN NNLGPVLSPT NVGSNTY