ID   IAPP_LEPEU              Reviewed;          23 AA.
AC   Q07333;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 52.
DE   RecName: Full=Islet amyloid polypeptide;
DE   AltName: Full=Amylin;
DE   Flags: Fragment;
GN   Name=IAPP;
OS   Lepus europaeus (European hare).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Lepus.
OX   NCBI_TaxID=9983;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pancreas;
RX   PubMed=8462765; DOI=10.1007/bf00399947;
RA   Christmanson L., Betsholtz C., Leckstroem A., Engstroem U., Cortie C.,
RA   Johnson K.H., Adrian T.E., Westermark P.;
RT   "Islet amyloid polypeptide in the rabbit and European hare: studies on its
RT   relationship to amyloidogenesis.";
RL   Diabetologia 36:183-188(1993).
CC   -!- FUNCTION: Selectively inhibits insulin-stimulated glucose utilization
CC       and glycogen deposition in muscle, while not affecting adipocyte
CC       glucose metabolism. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with IDE and INS. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- DOMAIN: The mature protein is largely unstructured in the absence of a
CC       cognate ligand. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the calcitonin family. {ECO:0000305}.
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DR   EMBL; S57802; AAB26083.1; -; mRNA.
DR   PIR; I46933; I46933.
DR   AlphaFoldDB; Q07333; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Amyloid; Hormone; Secreted.
FT   PEPTIDE         <1..>23
FT                   /note="Islet amyloid polypeptide"
FT                   /id="PRO_0000004108"
FT   NON_TER         1
FT   NON_TER         23
SQ   SEQUENCE   23 AA;  2546 MW;  A5EE561D52B353DD CRC64;
     TQRLANFLIH SSNNFGAIFS PPN