ID   IAPP_MESAU              Reviewed;          92 AA.
AC   P23442;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1991, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Islet amyloid polypeptide;
DE   AltName: Full=Amylin;
DE   Flags: Precursor;
GN   Name=IAPP;
OS   Mesocricetus auratus (Golden hamster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Mesocricetus.
OX   NCBI_TaxID=10036;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2251153; DOI=10.1093/nar/18.22.6726;
RA   Nishi M., Bell G.I., Steiner D.F.;
RT   "Sequence of a cDNA encoding Syrian hamster islet amyloid polypeptide
RT   precursor.";
RL   Nucleic Acids Res. 18:6726-6726(1990).
CC   -!- FUNCTION: Selectively inhibits insulin-stimulated glucose utilization
CC       and glycogen deposition in muscle, while not affecting adipocyte
CC       glucose metabolism. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with IDE and INS. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- DOMAIN: The mature protein is largely unstructured in the absence of a
CC       cognate ligand. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the calcitonin family. {ECO:0000305}.
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DR   EMBL; X56067; CAA39545.1; -; mRNA.
DR   PIR; S13116; S13116.
DR   RefSeq; NP_001268503.1; NM_001281574.1.
DR   AlphaFoldDB; P23442; -.
DR   BMRB; P23442; -.
DR   STRING; 10036.XP_005072971.1; -.
DR   GeneID; 101832022; -.
DR   CTD; 3375; -.
DR   eggNOG; ENOG502S4AQ; Eukaryota.
DR   OrthoDB; 1454612at2759; -.
DR   Proteomes; UP000189706; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR021117; Calcitonin-like.
DR   InterPro; IPR021116; Calcitonin/adrenomedullin.
DR   InterPro; IPR018360; Calcitonin_CS.
DR   InterPro; IPR001693; Calcitonin_peptide-like.
DR   InterPro; IPR000443; IAPP.
DR   PANTHER; PTHR10505; PTHR10505; 2.
DR   PANTHER; PTHR10505:SF4; PTHR10505:SF4; 2.
DR   Pfam; PF00214; Calc_CGRP_IAPP; 1.
DR   PRINTS; PR00818; ISLETAMYLOID.
DR   SMART; SM00113; CALCITONIN; 1.
DR   PROSITE; PS00258; CALCITONIN; 1.
PE   3: Inferred from homology;
KW   Amidation; Amyloid; Cleavage on pair of basic residues; Disulfide bond;
KW   Hormone; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..34
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000004109"
FT   PEPTIDE         37..73
FT                   /note="Islet amyloid polypeptide"
FT                   /id="PRO_0000004110"
FT   PROPEP          77..92
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000004111"
FT   MOD_RES         73
FT                   /note="Tyrosine amide"
FT                   /evidence="ECO:0000250"
FT   DISULFID        38..43
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   92 AA;  9899 MW;  6D2F7359C4A1D029 CRC64;
     MHISKLPAAL LIFSVALNHL KATPVRSGTN HQMDKRKCNT ATCATQRLAN FLVHSNNNLG
     PVLSPTNVGS NTYGKRSAAE IPDGDSLDLF LL