ID   IAPP_PIG                Reviewed;          32 AA.
AC   Q29119;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Islet amyloid polypeptide;
DE   AltName: Full=Amylin;
DE   Flags: Fragment;
GN   Name=IAPP;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Albrandt K., Sierzega M.E., Mull E., Brady E.M.G.;
RT   "PCR amplification of amylin 3-34 from genomic DNA.";
RL   Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Selectively inhibits insulin-stimulated glucose utilization
CC       and glycogen deposition in muscle, while not affecting adipocyte
CC       glucose metabolism. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with IDE and INS. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- DOMAIN: The mature protein is largely unstructured in the absence of a
CC       cognate ligand. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the calcitonin family. {ECO:0000305}.
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DR   EMBL; U62628; AAB05919.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q29119; -.
DR   STRING; 9823.ENSSSCP00000000612; -.
DR   PaxDb; Q29119; -.
DR   eggNOG; ENOG502S4AQ; Eukaryota.
DR   HOGENOM; CLU_189304_0_0_1; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   Genevisible; Q29119; SS.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR021116; Calcitonin/adrenomedullin.
DR   InterPro; IPR000443; IAPP.
DR   Pfam; PF00214; Calc_CGRP_IAPP; 1.
DR   PRINTS; PR00818; ISLETAMYLOID.
PE   3: Inferred from homology;
KW   Amyloid; Hormone; Reference proteome; Secreted.
FT   PEPTIDE         <1..>32
FT                   /note="Islet amyloid polypeptide"
FT                   /id="PRO_0000004118"
FT   NON_TER         1
FT   NON_TER         32
SQ   SEQUENCE   32 AA;  3466 MW;  7EB37E990EE555C8 CRC64;
     NMATCATQHL ANFLDRSRNN LGTIFSPTKV GS