IAPP_SHEEP
ID IAPP_SHEEP Reviewed; 32 AA.
AC Q28605;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 65.
DE RecName: Full=Islet amyloid polypeptide;
DE AltName: Full=Amylin;
DE Flags: Fragment;
GN Name=IAPP;
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Albrandt K., Sierzega M.E., Mull E., Brady E.M.G.;
RT "PCR amplification of amylin 3-34 from genomic DNA.";
RL Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Selectively inhibits insulin-stimulated glucose utilization
CC and glycogen deposition in muscle, while not affecting adipocyte
CC glucose metabolism. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with IDE and INS. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- DOMAIN: The mature protein is largely unstructured in the absence of a
CC cognate ligand. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the calcitonin family. {ECO:0000305}.
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DR EMBL; U62629; AAB05916.1; -; Genomic_DNA.
DR AlphaFoldDB; Q28605; -.
DR SMR; Q28605; -.
DR Proteomes; UP000002356; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR InterPro; IPR021116; Calcitonin/adrenomedullin.
DR InterPro; IPR000443; IAPP.
DR Pfam; PF00214; Calc_CGRP_IAPP; 1.
DR PRINTS; PR00818; ISLETAMYLOID.
PE 3: Inferred from homology;
KW Amyloid; Hormone; Reference proteome; Secreted.
FT PEPTIDE <1..>32
FT /note="Islet amyloid polypeptide"
FT /id="PRO_0000004125"
FT NON_TER 1
FT NON_TER 32
SQ SEQUENCE 32 AA; 3300 MW; CB5609394EB44C05 CRC64;
GTATCETQRL ANFLAPSSNK LGAIFSPTKM GS