ID   IAPP_SHEEP              Reviewed;          32 AA.
AC   Q28605;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Islet amyloid polypeptide;
DE   AltName: Full=Amylin;
DE   Flags: Fragment;
GN   Name=IAPP;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Albrandt K., Sierzega M.E., Mull E., Brady E.M.G.;
RT   "PCR amplification of amylin 3-34 from genomic DNA.";
RL   Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Selectively inhibits insulin-stimulated glucose utilization
CC       and glycogen deposition in muscle, while not affecting adipocyte
CC       glucose metabolism. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with IDE and INS. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- DOMAIN: The mature protein is largely unstructured in the absence of a
CC       cognate ligand. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the calcitonin family. {ECO:0000305}.
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DR   EMBL; U62629; AAB05916.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q28605; -.
DR   SMR; Q28605; -.
DR   Proteomes; UP000002356; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR021116; Calcitonin/adrenomedullin.
DR   InterPro; IPR000443; IAPP.
DR   Pfam; PF00214; Calc_CGRP_IAPP; 1.
DR   PRINTS; PR00818; ISLETAMYLOID.
PE   3: Inferred from homology;
KW   Amyloid; Hormone; Reference proteome; Secreted.
FT   PEPTIDE         <1..>32
FT                   /note="Islet amyloid polypeptide"
FT                   /id="PRO_0000004125"
FT   NON_TER         1
FT   NON_TER         32
SQ   SEQUENCE   32 AA;  3300 MW;  CB5609394EB44C05 CRC64;
     GTATCETQRL ANFLAPSSNK LGAIFSPTKM GS