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IAP_GVCPM
ID   IAP_GVCPM               Reviewed;         275 AA.
AC   P41436;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Apoptosis inhibitor IAP;
GN   Name=IAP;
OS   Cydia pomonella granulosis virus (isolate Mexico/1963) (CpGV) (Cydia
OS   pomonella granulovirus).
OC   Viruses; Naldaviricetes; Lefavirales; Baculoviridae; Betabaculovirus.
OX   NCBI_TaxID=654905;
OH   NCBI_TaxID=82600; Cydia pomonella (Codling moth).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Mexican 1;
RX   PubMed=8445726; DOI=10.1128/jvi.67.4.2168-2174.1993;
RA   Crook N.E., Clem R.J., Miller L.K.;
RT   "An apoptosis-inhibiting baculovirus gene with a zinc finger-like motif.";
RL   J. Virol. 67:2168-2174(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Mexican 1;
RX   PubMed=9237352; DOI=10.1023/a:1007917317770;
RA   Kang W., Crook N.E., Winstanley D., O'Reilly D.R.;
RT   "Complete sequence and transposon mutagenesis of the BamHI J fragment of
RT   Cydia pomonella granulosis virus.";
RL   Virus Genes 14:131-136(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Mexican 1;
RX   PubMed=11562546; DOI=10.1099/0022-1317-82-10-2531;
RA   Luque T., Finch R., Crook N., O'Reilly D.R., Winstanley D.;
RT   "The complete sequence of the Cydia pomonella granulovirus genome.";
RL   J. Gen. Virol. 82:2531-2547(2001).
CC   -!- FUNCTION: Acts by blocking cellular apoptosis rather than by preventing
CC       viral stimulation of apoptosis.
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DR   EMBL; U53466; AAB39098.1; -; Genomic_DNA.
DR   PIR; A45679; A45679.
DR   RefSeq; NP_148801.1; NC_002816.1.
DR   SMR; P41436; -.
DR   MEROPS; I32.010; -.
DR   GeneID; 921387; -.
DR   KEGG; vg:921387; -.
DR   Proteomes; UP000009249; Genome.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd00022; BIR; 2.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR001370; BIR_rpt.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   Pfam; PF00653; BIR; 2.
DR   SMART; SM00238; BIR; 2.
DR   PROSITE; PS01282; BIR_REPEAT_1; 2.
DR   PROSITE; PS50143; BIR_REPEAT_2; 2.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   4: Predicted;
KW   Apoptosis; Metal-binding; Reference proteome; Repeat; Zinc; Zinc-finger.
FT   CHAIN           1..275
FT                   /note="Apoptosis inhibitor IAP"
FT                   /id="PRO_0000122372"
FT   REPEAT          7..73
FT                   /note="BIR 1"
FT   REPEAT          108..175
FT                   /note="BIR 2"
FT   ZN_FING         228..263
FT                   /note="RING-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT   BINDING         145
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00029"
FT   BINDING         148
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00029"
FT   BINDING         165
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00029"
FT   BINDING         172
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00029"
SQ   SEQUENCE   275 AA;  31290 MW;  84605448869CAD60 CRC64;
     MSDLRLEEVR LNTFEKWPVS FLSPETMAKN GFYYLGRSDE VRCAFCKVEI MRWKEGEDPA
     ADHKKWAPQC PFVKGIDVCG SIVTTNNIQN TTTHDTIIGP AHPKYAHEAA RVKSFHNWPR
     CMKQRPEQMA DAGFFYTGYG DNTKCFYCDG GLKDWEPEDV PWEQHVRWFD RCAYVQLVKG
     RDYVQKVITE ACVLPGENTT VSTAAPVSEP IPETKIEKEP QVEDSKLCKI CYVEECIVCF
     VPCGHVVACA KCALSVDKCP MCRKIVTSVL KVYFS
 
 
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