IAR1_ARATH
ID IAR1_ARATH Reviewed; 469 AA.
AC Q9M647; Q8H9F6; Q8VYF8; Q9C9X4;
DT 24-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 29-MAY-2007, sequence version 3.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=IAA-alanine resistance protein 1;
DE Flags: Precursor;
GN Name=IAR1; OrderedLocusNames=At1g68100; ORFNames=T23K23.5;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Landsberg erecta;
RX PubMed=11148286; DOI=10.2307/3871237;
RA Lasswell J.E., Rogg L.E., Nelson D.C., Rongey C., Bartel B.;
RT "Cloning and characterization of IAR1, a gene required for auxin conjugate
RT sensitivity in Arabidopsis.";
RL Plant Cell 12:2395-2408(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May participate in auxin metabolism or response. Probable
CC transporter.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC KE4/Catsup subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG52008.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AAL59930.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AF216524; AAF32299.1; -; mRNA.
DR EMBL; AC012563; AAG52008.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE34749.1; -; Genomic_DNA.
DR EMBL; AY072108; AAL59930.1; ALT_FRAME; mRNA.
DR EMBL; BT001920; AAN71919.1; -; mRNA.
DR EMBL; AK229148; BAF01022.1; -; mRNA.
DR EMBL; AY084533; AAM61101.1; -; mRNA.
DR RefSeq; NP_564921.1; NM_105480.3.
DR AlphaFoldDB; Q9M647; -.
DR BioGRID; 28359; 1.
DR STRING; 3702.AT1G68100.1; -.
DR TCDB; 2.A.5.4.7; the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.
DR iPTMnet; Q9M647; -.
DR PaxDb; Q9M647; -.
DR PRIDE; Q9M647; -.
DR ProteomicsDB; 248565; -.
DR EnsemblPlants; AT1G68100.1; AT1G68100.1; AT1G68100.
DR GeneID; 843138; -.
DR Gramene; AT1G68100.1; AT1G68100.1; AT1G68100.
DR KEGG; ath:AT1G68100; -.
DR Araport; AT1G68100; -.
DR TAIR; locus:2200266; AT1G68100.
DR eggNOG; KOG2693; Eukaryota.
DR HOGENOM; CLU_015114_0_1_1; -.
DR InParanoid; Q9M647; -.
DR OMA; IWLHSIG; -.
DR OrthoDB; 657777at2759; -.
DR PhylomeDB; Q9M647; -.
DR PRO; PR:Q9M647; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9M647; baseline and differential.
DR Genevisible; Q9M647; AT.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:TAIR.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006882; P:cellular zinc ion homeostasis; IBA:GO_Central.
DR GO; GO:0071577; P:zinc ion transmembrane transport; IBA:GO_Central.
DR InterPro; IPR003689; ZIP.
DR Pfam; PF02535; Zip; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix;
KW Transport.
FT SIGNAL 1..28
FT /evidence="ECO:0000255"
FT CHAIN 29..469
FT /note="IAA-alanine resistance protein 1"
FT /id="PRO_0000213697"
FT TRANSMEM 114..134
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 201..221
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 387..407
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 415..435
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 448..468
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 33..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 170..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 228..315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 171..193
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..276
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 277..314
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 469 AA; 50583 MW; AA81A5EA420A78D8 CRC64;
MSFSLRKLLV PILVLVLFLD LCVESGFSQS TPARDDHVHH HGGGCSHSHD HDHDHDHDHH
VKKTTAKVEM KLPEELAEEE DMRLCGFGPC LHDHDHESSS TLTGFALWLN ALGCSLLVSL
ASLICLVLLP IMFVQGKPSK WFVDSLALFG AGAMLGDAFL HQLPHAFGGG HSHSNDHHEN
HDHHDHSHSD SPSHSHSIQD LSVGLSVLAG IVVFLLVEKL VRYVEENSSG SNTWGHHHHH
HHAGSKKLKD EGDHNNLDQQ SSSDAIVNSS EKVSGGSTDK SLRKRKTSAS DATDKSDSGT
EITSDGKSDK PEQVETRSSS LVFGYLNLFS DGVHNFTDGM ALGSAFLIYG SVGGWSRTMF
LLAHELPQEI GDFGILVRSG FTVTKALFFN FLSALVALAG TALVLVWGNE PGQSSLIEGF
TAGGFIYIAV AGVLAEMNNS GKSTLKNSAC HLISLILGMS VALCISLIE
