ID   IBB1_COILA              Reviewed;          64 AA.
AC   P07679;
DT   01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1988, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Bowman-Birk type trypsin inhibitor TI1;
OS   Coix lacryma-jobi (Job's tears).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC   Panicoideae; Andropogonodae; Andropogoneae; Rottboelliinae; Coix.
OX   NCBI_TaxID=4505;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=3162215; DOI=10.1016/0014-5793(88)80808-1;
RA   Ary M.B., Shewry P.R., Richardson M.;
RT   "The amino acid sequence of a cereal Bowman-Birk type trypsin inhibitor
RT   from seeds of Jobs' tears (Coix lachryma-jobi L.).";
RL   FEBS Lett. 229:111-118(1988).
CC   -!- SIMILARITY: Belongs to the Bowman-Birk serine protease inhibitor
CC       family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   PIR; S00349; TIOAB.
DR   AlphaFoldDB; P07679; -.
DR   SMR; P07679; -.
DR   MEROPS; I12.009; -.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   CDD; cd00023; BBI; 1.
DR   Gene3D; 2.10.69.10; -; 1.
DR   InterPro; IPR035995; Bowman-Birk_prot_inh.
DR   InterPro; IPR000877; Prot_inh_BBI.
DR   Pfam; PF00228; Bowman-Birk_leg; 1.
DR   SMART; SM00269; BowB; 1.
DR   SUPFAM; SSF57247; SSF57247; 1.
DR   PROSITE; PS00281; BOWMAN_BIRK; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Protease inhibitor;
KW   Serine protease inhibitor.
FT   CHAIN           1..64
FT                   /note="Bowman-Birk type trypsin inhibitor TI1"
FT                   /id="PRO_0000105836"
FT   SITE            17..18
FT                   /note="Reactive bond for trypsin"
FT                   /evidence="ECO:0000250"
FT   DISULFID        9..61
FT                   /evidence="ECO:0000250|UniProtKB:P80321"
FT   DISULFID        10..25
FT                   /evidence="ECO:0000250|UniProtKB:P80321"
FT   DISULFID        15..23
FT                   /evidence="ECO:0000250|UniProtKB:P80321"
FT   DISULFID        32..39
FT                   /evidence="ECO:0000250|UniProtKB:P80321"
FT   DISULFID        36..49
FT                   /evidence="ECO:0000250|UniProtKB:P80321"
SQ   SEQUENCE   64 AA;  7270 MW;  2ED0EEFFF063E891 CRC64;
     GDEKRPWECC DIAMCTRSIP PICRCVDKVD RCSDACKDCE ETEDNRHVCF DTYIGDPGPT
     CHDD