ID   IBB2_SETIT              Reviewed;          67 AA.
AC   P19860;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Bowman-Birk type major trypsin inhibitor;
DE   AltName: Full=FMTI-II;
OS   Setaria italica (Foxtail millet) (Panicum italicum).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC   Panicoideae; Panicodae; Paniceae; Cenchrinae; Setaria.
OX   NCBI_TaxID=4555;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=2292595; DOI=10.1093/oxfordjournals.jbchem.a123260;
RA   Tashiro M., Asao T., Hirata C., Takahashi K., Kanamori M.;
RT   "The complete amino acid sequence of a major trypsin inhibitor from seeds
RT   of foxtail millet (Setaria italica).";
RL   J. Biochem. 108:669-672(1990).
CC   -!- SIMILARITY: Belongs to the Bowman-Birk serine protease inhibitor
CC       family. {ECO:0000305}.
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DR   PIR; JX0136; TIILF2.
DR   AlphaFoldDB; P19860; -.
DR   SMR; P19860; -.
DR   Proteomes; UP000004995; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   CDD; cd00023; BBI; 1.
DR   Gene3D; 2.10.69.10; -; 1.
DR   InterPro; IPR035995; Bowman-Birk_prot_inh.
DR   InterPro; IPR000877; Prot_inh_BBI.
DR   Pfam; PF00228; Bowman-Birk_leg; 1.
DR   SMART; SM00269; BowB; 1.
DR   SUPFAM; SSF57247; SSF57247; 1.
DR   PROSITE; PS00281; BOWMAN_BIRK; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Protease inhibitor;
KW   Reference proteome; Serine protease inhibitor.
FT   CHAIN           1..67
FT                   /note="Bowman-Birk type major trypsin inhibitor"
FT                   /id="PRO_0000105839"
FT   SITE            16..17
FT                   /note="Reactive bond for trypsin"
FT                   /evidence="ECO:0000250"
FT   DISULFID        8..63
FT                   /evidence="ECO:0000250|UniProtKB:P80321"
FT   DISULFID        9..24
FT                   /evidence="ECO:0000250|UniProtKB:P80321"
FT   DISULFID        14..22
FT                   /evidence="ECO:0000250|UniProtKB:P80321"
FT   DISULFID        31..38
FT                   /evidence="ECO:0000250|UniProtKB:P80321"
FT   DISULFID        35..51
FT                   /evidence="ECO:0000250|UniProtKB:P80321"
SQ   SEQUENCE   67 AA;  7679 MW;  109AF30F33248949 CRC64;
     SGERPWKCCD LQTCTKSIPA FCRCRDLLEQ CSDACKECGK VRDSDPPRYI CQDVYRGIPA
     PMCHEHQ