ID   IBB3_WHEAT              Reviewed;          71 AA.
AC   P81713;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Bowman-Birk type trypsin inhibitor;
DE            Short=WTI;
OS   Triticum aestivum (Wheat).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX   NCBI_TaxID=4565;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   STRAIN=cv. San Pastore; TISSUE=Endosperm;
RX   PubMed=8060492; DOI=10.1007/bf01891977;
RA   Poerio E., Caporale C., Carrano L., Caruso C., Vacca F., Buonocore V.;
RT   "The amino acid sequence and reactive site of a single-headed trypsin
RT   inhibitor from wheat endosperm.";
RL   J. Protein Chem. 13:187-194(1994).
CC   -!- FUNCTION: Inhibits trypsin but not chymotrypsin.
CC   -!- SIMILARITY: Belongs to the Bowman-Birk serine protease inhibitor
CC       family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; P81713; -.
DR   SMR; P81713; -.
DR   PRIDE; P81713; -.
DR   Proteomes; UP000019116; Unplaced.
DR   ExpressionAtlas; P81713; baseline.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   CDD; cd00023; BBI; 1.
DR   Gene3D; 2.10.69.10; -; 1.
DR   InterPro; IPR035995; Bowman-Birk_prot_inh.
DR   InterPro; IPR000877; Prot_inh_BBI.
DR   Pfam; PF00228; Bowman-Birk_leg; 1.
DR   SMART; SM00269; BowB; 1.
DR   SUPFAM; SSF57247; SSF57247; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Protease inhibitor;
KW   Reference proteome; Serine protease inhibitor.
FT   CHAIN           1..71
FT                   /note="Bowman-Birk type trypsin inhibitor"
FT                   /id="PRO_0000105860"
FT   SITE            19..20
FT                   /note="Reactive bond for trypsin"
FT   DISULFID        10..67
FT                   /evidence="ECO:0000250|UniProtKB:P80321"
FT   DISULFID        11..27
FT                   /evidence="ECO:0000250|UniProtKB:P80321"
FT   DISULFID        14..63
FT                   /evidence="ECO:0000250|UniProtKB:P80321"
FT   DISULFID        17..25
FT                   /evidence="ECO:0000250|UniProtKB:P80321"
FT   DISULFID        35..42
FT                   /evidence="ECO:0000250|UniProtKB:P80321"
FT   DISULFID        39..55
FT                   /evidence="ECO:0000250|UniProtKB:P80321"
SQ   SEQUENCE   71 AA;  7962 MW;  71D70BD7C30D4DDE CRC64;
     EEAMPSAWPC CDECGTCTRM IPPRCTCMDV SPSGCHPACK NCVQTTLGGR DVFWCMLRIE
     NFCKRRCTPA R