IBBC2_SOYBN
ID IBBC2_SOYBN Reviewed; 83 AA.
AC P01063;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1989, sequence version 2.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Bowman-Birk type proteinase inhibitor C-II;
DE Flags: Precursor;
OS Glycine max (Soybean) (Glycine hispida).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; indigoferoid/millettioid clade; Phaseoleae; Glycine;
OC Glycine subgen. Soja.
OX NCBI_TaxID=3847;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX AGRICOLA=IND92000914; DOI=10.1007/BF00014184;
RA Joudrier P.E., Foard D.E., Floener L.A., Larkins B.A.;
RT "Isolation and sequence of cDNA encoding the soybean protease inhibitors PI
RT IV and C-II.";
RL Plant Mol. Biol. 10:35-42(1987).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Paldal; TISSUE=Seed;
RX PubMed=7764974; DOI=10.1271/bbb.58.843;
RA Baek J.M., Song J.C., Choi Y.D., Kim S.I.;
RT "Nucleotide sequence homology of cDNAs encoding soybean Bowman-Birk type
RT proteinase inhibitor and its isoinhibitors.";
RL Biosci. Biotechnol. Biochem. 58:843-846(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=cv. Maple Arrow;
RA Giordano A., Delledonne M., Fogher C., Marchetti S.;
RL Submitted (DEC-1993) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=6086657; DOI=10.1016/s0021-9258(17)42782-7;
RA Hammond R.W., Foard D.E., Larkins B.A.;
RT "Molecular cloning and analysis of a gene coding for the Bowman-Birk
RT protease inhibitor in soybean.";
RL J. Biol. Chem. 259:9883-9890(1984).
RN [5]
RP ERRATUM OF PUBMED:6086657, AND SEQUENCE REVISION.
RA Hammond R.W., Foard D.E., Larkins B.A.;
RL J. Biol. Chem. 260:7806-7806(1985).
RN [6]
RP PROTEIN SEQUENCE OF 8-83.
RX PubMed=599141; DOI=10.1093/oxfordjournals.jbchem.a131846;
RA Odani S., Ikenaka T.;
RT "Studies on soybean trypsin inhibitors. XI. Complete amino acid sequence of
RT a soybean trypsin-chymotrypsin-elastase inhibitor, C-II.";
RL J. Biochem. 82:1523-1531(1977).
CC -!- SIMILARITY: Belongs to the Bowman-Birk serine protease inhibitor
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA33952.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; M20732; AAA33953.1; -; mRNA.
DR EMBL; X68705; CAA48656.1; -; mRNA.
DR EMBL; X76727; CAA54144.1; -; Genomic_DNA.
DR EMBL; K01967; AAA33952.1; ALT_INIT; Genomic_DNA.
DR PIR; A22636; TISYC2.
DR PIR; S07405; S07405.
DR RefSeq; NP_001238409.1; NM_001251480.1.
DR AlphaFoldDB; P01063; -.
DR SMR; P01063; -.
DR MEROPS; I12.001; -.
DR MEROPS; I12.008; -.
DR PRIDE; P01063; -.
DR EnsemblPlants; KRH15895; KRH15895; GLYMA_14G117600.
DR EnsemblPlants; KRH38802; KRH38802; GLYMA_09G158800.
DR GeneID; 547818; -.
DR Gramene; KRH15895; KRH15895; GLYMA_14G117600.
DR Gramene; KRH38802; KRH38802; GLYMA_09G158800.
DR KEGG; gmx:547818; -.
DR Proteomes; UP000008827; Chromosome 14.
DR Proteomes; UP000008827; Chromosome 9.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR CDD; cd00023; BBI; 1.
DR Gene3D; 2.10.69.10; -; 1.
DR InterPro; IPR035995; Bowman-Birk_prot_inh.
DR InterPro; IPR000877; Prot_inh_BBI.
DR Pfam; PF00228; Bowman-Birk_leg; 2.
DR SMART; SM00269; BowB; 1.
DR SUPFAM; SSF57247; SSF57247; 1.
DR PROSITE; PS00281; BOWMAN_BIRK; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Protease inhibitor;
KW Reference proteome; Serine protease inhibitor.
FT PROPEP 1..7
FT /evidence="ECO:0000269|PubMed:599141"
FT /id="PRO_0000003282"
FT CHAIN 8..83
FT /note="Bowman-Birk type proteinase inhibitor C-II"
FT /id="PRO_0000003283"
FT SITE 29..30
FT /note="Reactive bond for elastase"
FT /evidence="ECO:0000250"
FT SITE 56..57
FT /note="Reactive bond for trypsin and chymotrypsin"
FT DISULFID 21..75
FT /evidence="ECO:0000250|UniProtKB:P80321"
FT DISULFID 22..37
FT /evidence="ECO:0000250|UniProtKB:P80321"
FT DISULFID 25..71
FT /evidence="ECO:0000250|UniProtKB:P80321"
FT DISULFID 27..35
FT /evidence="ECO:0000250|UniProtKB:P80321"
FT DISULFID 45..52
FT /evidence="ECO:0000250|UniProtKB:P80321"
FT DISULFID 49..64
FT /evidence="ECO:0000250|UniProtKB:P80321"
FT DISULFID 54..62
FT /evidence="ECO:0000250|UniProtKB:P80321"
FT CONFLICT 4
FT /note="N -> D (in Ref. 4; AAA33952)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 83 AA; 9201 MW; 93A4F786F7206DCA CRC64;
MELNLFKSDH SSSDDESSKP CCDLCMCTAS MPPQCHCADI RLNSCHSACD RCACTRSMPG
QCRCLDTTDF CYKPCKSSDE DDD
