ID   IBD2_KLULA              Reviewed;         335 AA.
AC   Q6CRM3;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Protein IBD2;
GN   Name=IBD2; OrderedLocusNames=KLLA0D07920g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Part of a checkpoint which monitors spindle integrity and
CC       prevents premature exit from mitosis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle pole
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IBD2 family. {ECO:0000305}.
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DR   EMBL; CR382124; CAH00512.1; -; Genomic_DNA.
DR   RefSeq; XP_453416.1; XM_453416.1.
DR   AlphaFoldDB; Q6CRM3; -.
DR   STRING; 28985.XP_453416.1; -.
DR   EnsemblFungi; CAH00512; CAH00512; KLLA0_D07920g.
DR   GeneID; 2893181; -.
DR   KEGG; kla:KLLA0_D07920g; -.
DR   eggNOG; ENOG502RXXW; Eukaryota.
DR   HOGENOM; CLU_067888_0_0_1; -.
DR   InParanoid; Q6CRM3; -.
DR   Proteomes; UP000000598; Chromosome D.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007094; P:mitotic spindle assembly checkpoint signaling; IEA:InterPro.
DR   InterPro; IPR026231; IBD2.
DR   PRINTS; PR02099; PROTEINIBD2.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cytoplasm; Cytoskeleton; Mitosis;
KW   Reference proteome.
FT   CHAIN           1..335
FT                   /note="Protein IBD2"
FT                   /id="PRO_0000333336"
FT   REGION          203..225
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          296..335
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        203..217
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        299..320
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        321..335
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   335 AA;  37902 MW;  26310BB9802BD4A8 CRC64;
     MGNGNASIEF VSENGPIDFS VMMQEGVKAL TKILSTHLQD NPDLINEKSM KVIFKDNNGK
     LEPVFAPSEG NSGLINGNDQ DENYDEDRDI EEANEDYEVI EFDNEGNYHV CAKGTQNRAI
     GYDEKVYSKS EHYADSTDTH DYDEDGIINE DNNQLLPKDK WNGHMTRLKN GAISSAEHEV
     VFEHDNGDNT TFSPAETIND GHMDKRDRSH MHHSGHSEKT GGSCACQENK DSFKYPDHVP
     NSAPNFRALL QHTVNGKQMC PFCEYYVVFG TPPAYIMRWA SSKISAEHSQ YKMNDQIVDG
     DSGDMDRNLD SVETNEMNKQ QTKKKKKKSK RKSKR