ID   IBD2_VANPO              Reviewed;         341 AA.
AC   A7TMZ9;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 53.
DE   RecName: Full=Protein IBD2;
GN   Name=IBD2; ORFNames=Kpol_1051p37;
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS   2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX   NCBI_TaxID=436907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL
RC   Y-8283 / UCD 57-17;
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT   species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- FUNCTION: Part of a checkpoint which monitors spindle integrity and
CC       prevents premature exit from mitosis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle pole
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IBD2 family. {ECO:0000305}.
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DR   EMBL; DS480426; EDO16387.1; -; Genomic_DNA.
DR   RefSeq; XP_001644245.1; XM_001644195.1.
DR   AlphaFoldDB; A7TMZ9; -.
DR   STRING; 436907.A7TMZ9; -.
DR   EnsemblFungi; EDO16387; EDO16387; Kpol_1051p37.
DR   GeneID; 5544528; -.
DR   KEGG; vpo:Kpol_1051p37; -.
DR   eggNOG; ENOG502RXXW; Eukaryota.
DR   HOGENOM; CLU_067888_0_0_1; -.
DR   InParanoid; A7TMZ9; -.
DR   OMA; PKNMIKW; -.
DR   OrthoDB; 1366582at2759; -.
DR   PhylomeDB; A7TMZ9; -.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007094; P:mitotic spindle assembly checkpoint signaling; IEA:InterPro.
DR   InterPro; IPR026231; IBD2.
DR   PRINTS; PR02099; PROTEINIBD2.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cytoplasm; Cytoskeleton; Mitosis;
KW   Reference proteome.
FT   CHAIN           1..341
FT                   /note="Protein IBD2"
FT                   /id="PRO_0000333338"
FT   REGION          211..264
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        213..235
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        245..264
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   341 AA;  38958 MW;  5BFACA9AE9DAF970 CRC64;
     MAKTQIRNGT SIEVVSEDGP LPINVMMQEG VKALTKILSD HLQDGQSVDN ESHSMQFVFK
     NVNDALDEAN YQNPEGNGDV KISEIKSDGE SDVVNFEVQD MKRKTLDEDD SIEEYITDPQ
     LHLDGDKGEI VFDYGSEIIT DNPEGIGERI SQMIESVLPN GFPRDSRGRL HAVVNGDELN
     ITEETDIDVT YSNEPVTSGY IDGIEYNEDE DSYEHDGCCP HHHHQTQDQQ NNRQYHHHHS
     RQTHSQSQHP LSKQPPTSSK YRNYNYHDYN YEDDQESIPV GNAPNFSMLM TGNHNLCLFC
     EYYMVFGEAP KNMIKWYNKN YGYDRLPQSS ARNGNSRKSN R