IBL1_ARATH
ID IBL1_ARATH Reviewed; 180 AA.
AC Q9M0B9;
DT 12-APR-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Transcription factor IBH1-like 1 {ECO:0000303|PubMed:24505057};
DE Short=AtIBL1 {ECO:0000303|PubMed:24505057};
DE AltName: Full=BHLH transcription factor eta;
DE Short=bHLH eta {ECO:0000312|EMBL:CAE09173.1};
DE AltName: Full=Basic helix-loop-helix protein 159;
DE Short=AtbHLH159 {ECO:0000303|PubMed:14600211};
DE Short=bHLH 159;
DE AltName: Full=bHLH transcription factor bHLH159;
GN Name=IBL1 {ECO:0000303|PubMed:24505057};
GN Synonyms=BHLH159 {ECO:0000303|PubMed:14600211};
GN OrderedLocusNames=At4g30410 {ECO:0000312|Araport:AT4G30410};
GN ORFNames=F17I23.250 {ECO:0000312|EMBL:AF160182};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, AND NOMENCLATURE.
RX PubMed=14600211; DOI=10.1105/tpc.151140;
RA Bailey P.C., Martin C., Toledo-Ortiz G., Quail P.H., Huq E., Heim M.A.,
RA Jakoby M., Werber M., Weisshaar B.;
RT "Update on the basic helix-loop-helix transcription factor gene family in
RT Arabidopsis thaliana.";
RL Plant Cell 15:2497-2502(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=24505057; DOI=10.1073/pnas.1400203111;
RA Zhiponova M.K., Morohashi K., Vanhoutte I., Machemer-Noonan K.,
RA Revalska M., Van Montagu M., Grotewold E., Russinova E.;
RT "Helix-loop-helix/basic helix-loop-helix transcription factor network
RT represses cell elongation in Arabidopsis through an apparent incoherent
RT feed-forward loop.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:2824-2829(2014).
CC -!- FUNCTION: Functions redundandly with IBH1/BHLH158 in a regulation node
CC known as the incoherent feed-forward loop (FFL). Acts as
CC transcriptional repressor that negatively regulates cell and organ
CC elongation in response to gibberellin (GA) and brassinosteroid (BR)
CC signaling. {ECO:0000269|PubMed:24505057}.
CC -!- INTERACTION:
CC Q9M0B9; Q93VJ4: BEE2; NbExp=3; IntAct=EBI-15192969, EBI-4424312;
CC Q9M0B9; Q3EAI1-2: BHLH60; NbExp=3; IntAct=EBI-15192969, EBI-15194889;
CC Q9M0B9; Q9LK48: BHLH77; NbExp=3; IntAct=EBI-15192969, EBI-15192967;
CC Q9M0B9; Q9ZPW3-2: HBI1; NbExp=3; IntAct=EBI-15192969, EBI-15197377;
CC Q9M0B9; Q9LJX1: PRE5; NbExp=5; IntAct=EBI-15192969, EBI-15195291;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype.
CC {ECO:0000269|PubMed:24505057}.
CC -!- MISCELLANEOUS: Plants over-expressing IBL1 are dwarf with round-shaped,
CC dark-green leaves and short petioles. {ECO:0000269|PubMed:24505057}.
CC -!- SIMILARITY: Belongs to the bHLH protein family. {ECO:0000305}.
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DR EMBL; AJ576046; CAE09173.1; -; mRNA.
DR EMBL; AF160182; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL161577; CAB79759.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE85761.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE85762.1; -; Genomic_DNA.
DR EMBL; BT006398; AAP21206.1; -; mRNA.
DR EMBL; AK227688; BAE99675.1; -; mRNA.
DR PIR; F85355; F85355.
DR RefSeq; NP_194770.1; NM_119187.4.
DR RefSeq; NP_974640.1; NM_202911.2.
DR AlphaFoldDB; Q9M0B9; -.
DR SMR; Q9M0B9; -.
DR IntAct; Q9M0B9; 15.
DR STRING; 3702.AT4G30410.2; -.
DR PaxDb; Q9M0B9; -.
DR PRIDE; Q9M0B9; -.
DR ProteomicsDB; 232197; -.
DR EnsemblPlants; AT4G30410.1; AT4G30410.1; AT4G30410.
DR EnsemblPlants; AT4G30410.2; AT4G30410.2; AT4G30410.
DR GeneID; 829164; -.
DR Gramene; AT4G30410.1; AT4G30410.1; AT4G30410.
DR Gramene; AT4G30410.2; AT4G30410.2; AT4G30410.
DR KEGG; ath:AT4G30410; -.
DR Araport; AT4G30410; -.
DR TAIR; locus:2118676; AT4G30410.
DR eggNOG; ENOG502RYWW; Eukaryota.
DR HOGENOM; CLU_088059_2_0_1; -.
DR InParanoid; Q9M0B9; -.
DR OMA; WIKGLQI; -.
DR OrthoDB; 1624450at2759; -.
DR PRO; PR:Q9M0B9; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q9M0B9; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0009742; P:brassinosteroid mediated signaling pathway; IMP:UniProtKB.
DR GO; GO:0009740; P:gibberellic acid mediated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0040008; P:regulation of growth; IMP:UniProtKB.
DR CDD; cd11444; bHLH_AtIBH1_like; 1.
DR InterPro; IPR044549; bHLH_AtIBH1-like.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR044660; IBH1-like.
DR PANTHER; PTHR33124; PTHR33124; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
PE 1: Evidence at protein level;
KW Brassinosteroid signaling pathway; DNA-binding;
KW Gibberellin signaling pathway; Growth regulation; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..180
FT /note="Transcription factor IBH1-like 1"
FT /id="PRO_0000439397"
FT DOMAIN 110..160
FT /note="bHLH"
FT /evidence="ECO:0000305"
SQ SEQUENCE 180 AA; 20435 MW; D3E31BF670AA9F50 CRC64;
MQPTSSMNEE FLKKWQMGLQ IFRPSIDNTS VHERKKAIKL SADVAMASLR KGTTCWSRAL
IEKTATEDNF LVRQMLSGIK AETLINKKLP KKTVCHRKIV RRSKKILRRK SKSASEEAAA
KAKRLVKRRT QGLRNVVPGG ELMSNDVLLL QETLDYIVSL QTQVNVMRSI VDAAEAEIER
