ID   IBMP_CAMVC              Reviewed;         520 AA.
AC   P03558;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Transactivator/viroplasmin protein;
DE            Short=Tav;
DE   AltName: Full=Inclusion body matrix protein;
GN   ORFNames=ORF VI;
OS   Cauliflower mosaic virus (strain CM-1841) (CaMV).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Caulimoviridae; Caulimovirus.
OX   NCBI_TaxID=10644;
OH   NCBI_TaxID=3702; Arabidopsis thaliana (Mouse-ear cress).
OH   NCBI_TaxID=3705; Brassica.
OH   NCBI_TaxID=3725; Raphanus.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6269062; DOI=10.1093/nar/9.12.2871;
RA   Gardner R.C., Howarth A.J., Hahn P., Brown-Luedi M., Shepherd R.J.,
RA   Messing J.;
RT   "The complete nucleotide sequence of an infectious clone of cauliflower
RT   mosaic virus by M13mp7 shotgun sequencing.";
RL   Nucleic Acids Res. 9:2871-2888(1981).
RN   [2]
RP   FUNCTION.
RX   PubMed=11572778; DOI=10.1016/s0092-8674(01)00487-1;
RA   Park H.S., Himmelbach A., Browning K.S., Hohn T., Ryabova L.A.;
RT   "A plant viral 'reinitiation' factor interacts with the host translational
RT   machinery.";
RL   Cell 106:723-733(2001).
CC   -!- FUNCTION: Enhances the ribosomal termination-reinitiation event leading
CC       to the translation of major open reading frames on the polycistronic
CC       viral RNAs. {ECO:0000269|PubMed:11572778}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm. Note=Found in cytoplasmic
CC       occlusion bodies.
CC   -!- MISCELLANEOUS: The inclusion bodies are the site of viral DNA
CC       synthesis, virion assembly and accumulation in the infected cell.
CC   -!- SIMILARITY: Belongs to the caulimoviridae viroplasmin family.
CC       {ECO:0000305}.
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DR   EMBL; V00140; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PIR; A04161; QQCV6C.
DR   SMR; P03558; -.
DR   Proteomes; UP000008438; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   GO; GO:0075525; P:viral translational termination-reinitiation; IDA:UniProtKB.
DR   Gene3D; 3.40.970.10; -; 1.
DR   InterPro; IPR009027; Ribosomal_L9/RNase_H1_N.
DR   InterPro; IPR011320; RNase_H1_N.
DR   InterPro; IPR037056; RNase_H1_N_sf.
DR   Pfam; PF01693; Cauli_VI; 1.
DR   SUPFAM; SSF55658; SSF55658; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Reference proteome; Translation regulation.
FT   CHAIN           1..520
FT                   /note="Transactivator/viroplasmin protein"
FT                   /id="PRO_0000222039"
FT   REGION          487..520
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   520 AA;  57907 MW;  F02E7885699B2F49 CRC64;
     MENIEKLLMQ EKILMLELDL VRAKISLARA NGSSQQGDLP LHRETPVKEE AVHSALATFT
     PTQVKAIPEQ TAPGKESTNP LMASILPKDM NPVQTGIRLA VPGDFLRPHQ GIPIPQKSEL
     SSIVAPLRAE SGIHHPHINY YVVYNGPHAG IYDDWGCTKA ATNGVPGVAY KKFATITEAR
     AAADAYTTSQ QTDRLNFIPK GEAQLKPKSF AKALTSPPKQ KAHWLTLGTK RPSSDPAPKE
     ISFAPEITMD DFLYLYDLGR KFDGEGDDTM FTTDNEKISL FNFRKNADPQ MVREAYAAGL
     IKTIYPSNNL QEIKYLPKKV KDAVKRFRTN CIKNTEKDIF LKIRSTIPVW TIQGLLHKPR
     QVIEIGVSKK VVPTESKAME SKIQIEDLTE LAVKTGEQFI QSLLRLNDKK KIFVNMVEHD
     TLVYSKNIKD TVSEDQRAIE TFQQRVISGN LLGFHCPAIC HFIKRTVEKE GGTYKCHHCD
     KGKAIVQDAS ADSGPKDGPP PTRSIVEKED VPTTSSKQVD