ID   APBC_MYCLE              Reviewed;         383 AA.
AC   P53382;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   11-JAN-2001, sequence version 2.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=Iron-sulfur cluster carrier protein {ECO:0000255|HAMAP-Rule:MF_02040};
GN   Name=mrp; OrderedLocusNames=ML1080;
OS   Mycobacterium leprae (strain TN).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Smith D.R., Robison K.;
RL   Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN;
RX   PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
CC   -!- FUNCTION: Binds and transfers iron-sulfur (Fe-S) clusters to target
CC       apoproteins. Can hydrolyze ATP. {ECO:0000255|HAMAP-Rule:MF_02040}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_02040}.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the MIP18 family.
CC       {ECO:0000305}.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the Mrp/NBP35 ATP-
CC       binding proteins family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA62909.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; U15180; AAA62909.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AL583920; CAC31461.1; -; Genomic_DNA.
DR   PIR; B87044; B87044.
DR   PIR; T45199; T45199.
DR   RefSeq; NP_301793.1; NC_002677.1.
DR   RefSeq; WP_010908117.1; NC_002677.1.
DR   AlphaFoldDB; P53382; -.
DR   SMR; P53382; -.
DR   STRING; 272631.ML1080; -.
DR   EnsemblBacteria; CAC31461; CAC31461; CAC31461.
DR   KEGG; mle:ML1080; -.
DR   PATRIC; fig|272631.5.peg.1934; -.
DR   Leproma; ML1080; -.
DR   eggNOG; COG0489; Bacteria.
DR   eggNOG; COG2151; Bacteria.
DR   HOGENOM; CLU_024839_0_0_11; -.
DR   OMA; NMAYFTP; -.
DR   Proteomes; UP000000806; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0140663; F:ATP-dependent FeS chaperone activity; IEA:InterPro.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:InterPro.
DR   Gene3D; 3.30.300.130; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_02040; Mrp_NBP35; 1.
DR   InterPro; IPR034904; FSCA_dom_sf.
DR   InterPro; IPR002744; MIP18-like.
DR   InterPro; IPR019591; Mrp/NBP35_ATP-bd.
DR   InterPro; IPR000808; Mrp_CS.
DR   InterPro; IPR044304; NUBPL-like.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR033756; YlxH/NBP35.
DR   PANTHER; PTHR42961; PTHR42961; 1.
DR   Pfam; PF01883; FeS_assembly_P; 1.
DR   Pfam; PF10609; ParA; 1.
DR   SUPFAM; SSF117916; SSF117916; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS01215; MRP; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Hydrolase; Iron; Iron-sulfur; Metal-binding;
KW   Nucleotide-binding; Reference proteome.
FT   CHAIN           1..383
FT                   /note="Iron-sulfur cluster carrier protein"
FT                   /id="PRO_0000184937"
FT   BINDING         127..134
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02040"
SQ   SEQUENCE   383 AA;  40544 MW;  4D5B8F23A0C8279E CRC64;
     MSRTDRNAAD LKSAVSTALA KVIDPELQRP ITELGMVKNI DIEPGGNVQV GIYLTIASCP
     KKSEISKRVT KAIADVPGTA AVEVSLDVMS DEQRTKLRKK LRGDAREPMI PFAQPNSLTR
     VYTVASGKGG VGKSTVTVNL ATAIAARGLA VGVLDADIHG HSIPRMMGSN QRPIQLESMI
     LPPIVHEVKV ISIGQFTEGN TPVIWRGPML HRALQQFLSD VYWGDLDVLM LDLPPGTGDI
     AISVAQLIPN AEILVVTTPQ LAAAEVAERA GSIALQTRQR IVGVVENMSG LMMPDGSRLQ
     VFGEGGGQQV AERLSRAVGT DVPLLGQIPL DPALVAAGDS GIPIVLNASD SPVGKELLRI
     ADGLSSRQRR LAGVSLGLDP SRR