ID   IBP2_ONCTS              Reviewed;          20 AA.
AC   P83628;
DT   10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 43.
DE   RecName: Full=Insulin-like growth factor-binding protein 2;
DE            Short=IBP-2;
DE            Short=IGF-binding protein 2;
DE            Short=IGFBP-2;
DE   Flags: Fragment;
GN   Name=igfbp2;
OS   Oncorhynchus tshawytscha (Chinook salmon) (Salmo tshawytscha).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=74940 {ECO:0000305};
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, GLYCOSYLATION, AND INDUCTION.
RC   TISSUE=Serum {ECO:0000269|PubMed:12765649};
RX   PubMed=12765649; DOI=10.1016/s0016-6480(03)00052-2;
RA   Shimizu M., Swanson P., Hara A., Dickhoff W.W.;
RT   "Purification of a 41-kDa insulin-like growth factor binding protein from
RT   serum of chinook salmon, Oncorhynchus tshawytscha.";
RL   Gen. Comp. Endocrinol. 132:103-111(2003).
CC   -!- FUNCTION: Inhibits IGF-mediated growth and developmental rates (By
CC       similarity). IGF-binding proteins prolong the half-life of the IGFs and
CC       have been shown to either inhibit or stimulate the growth promoting
CC       effects of the IGFs on cell culture. They alter the interaction of IGFs
CC       with their cell surface receptors. {ECO:0000250}.
CC   -!- SUBUNIT: Binds IGF2 more than IGF1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- INDUCTION: Up-regulated by growth hormone treatment and down-regulated
CC       by fasting. {ECO:0000269|PubMed:12765649}.
CC   -!- DOMAIN: The C-terminus is required for IGF-binding and growth
CC       inhibition. {ECO:0000250}.
CC   -!- PTM: N-glycosylated. {ECO:0000269|PubMed:12765649}.
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DR   AlphaFoldDB; P83628; -.
DR   Proteomes; UP000694402; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IC:UniProtKB.
DR   GO; GO:0005520; F:insulin-like growth factor binding; IDA:UniProtKB.
DR   GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Glycoprotein; Growth factor binding;
KW   Growth regulation; Reference proteome; Secreted.
FT   CHAIN           1..>20
FT                   /note="Insulin-like growth factor-binding protein 2"
FT                   /id="PRO_0000152772"
FT   DOMAIN          2..>20
FT                   /note="IGFBP N-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00653"
FT   NON_TER         20
FT                   /evidence="ECO:0000303|PubMed:12765649"
SQ   SEQUENCE   20 AA;  2287 MW;  51FA8D039BE3F405 CRC64;
     DLVFYCPKCT AERQTACPKL