IBP5_XENLA
ID IBP5_XENLA Reviewed; 265 AA.
AC Q90WV8;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Insulin-like growth factor-binding protein 5;
DE Short=IBP-5;
DE Short=IGF-binding protein 5;
DE Short=IGFBP-5;
DE Short=xIGFBP-5;
DE Flags: Precursor;
GN Name=igfbp5 {ECO:0000312|EMBL:AAL12250.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAL12250.1}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND
RP DEVELOPMENTAL STAGE.
RC TISSUE=Embryo {ECO:0000269|PubMed:11709186};
RX PubMed=11709186; DOI=10.1016/s1534-5807(01)00069-7;
RA Pera E.M., Wessely O., Li S.-Y., De Robertis E.M.;
RT "Neural and head induction by insulin-like growth factor signals.";
RL Dev. Cell 1:655-665(2001).
CC -!- FUNCTION: IGF-binding proteins prolong the half-life of the IGFs and
CC have been shown to either inhibit or stimulate the growth promoting
CC effects of the IGFs on cell culture. They alter the interaction of IGFs
CC with their cell surface receptors. Promotes anterior neural development
CC by stimulating insulin growth factor (IGF) signaling via IGF receptors.
CC {ECO:0000269|PubMed:11709186, ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11709186}.
CC -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically.
CC Expressed on the dorsal side during gastrulation. Becomes confined to
CC the floor plate, notochord and dorsal endoderm during neurulation.
CC Expressed in additional domains at the tailbud stage in cranial nerves,
CC ear vesicle, dorsal fin and somites. Dorsal midline expression becomes
CC restricted to the floor plate and hypochord.
CC {ECO:0000269|PubMed:11709186}.
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DR EMBL; AY052629; AAL12250.1; -; mRNA.
DR RefSeq; NP_001083938.1; NM_001090469.1.
DR RefSeq; XP_018089692.1; XM_018234203.1.
DR AlphaFoldDB; Q90WV8; -.
DR SMR; Q90WV8; -.
DR MEROPS; I31.952; -.
DR PRIDE; Q90WV8; -.
DR GeneID; 399201; -.
DR KEGG; xla:399201; -.
DR CTD; 399201; -.
DR Xenbase; XB-GENE-485077; igfbp5.L.
DR OMA; YTERCAL; -.
DR OrthoDB; 979270at2759; -.
DR Proteomes; UP000186698; Chromosome 9_10L.
DR Bgee; 399201; Expressed in internal ear and 19 other tissues.
DR GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR GO; GO:0005520; F:insulin-like growth factor binding; IEA:InterPro.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IMP:UniProtKB.
DR GO; GO:0048009; P:insulin-like growth factor receptor signaling pathway; IDA:UniProtKB.
DR GO; GO:0007399; P:nervous system development; IMP:UniProtKB.
DR CDD; cd00191; TY; 1.
DR Gene3D; 4.10.800.10; -; 1.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR012213; IGFBP-5.
DR InterPro; IPR000867; IGFBP-like.
DR InterPro; IPR022321; IGFBP_1-6_chordata.
DR InterPro; IPR017891; Insulin_GF-bd_Cys-rich_CS.
DR InterPro; IPR000716; Thyroglobulin_1.
DR InterPro; IPR036857; Thyroglobulin_1_sf.
DR PANTHER; PTHR11551:SF4; PTHR11551:SF4; 1.
DR Pfam; PF00219; IGFBP; 1.
DR Pfam; PF00086; Thyroglobulin_1; 1.
DR PRINTS; PR01976; IGFBPFAMILY.
DR PRINTS; PR01981; IGFBPFAMILY5.
DR SMART; SM00121; IB; 1.
DR SMART; SM00211; TY; 1.
DR SUPFAM; SSF57184; SSF57184; 1.
DR SUPFAM; SSF57610; SSF57610; 1.
DR PROSITE; PS00222; IGFBP_N_1; 1.
DR PROSITE; PS51323; IGFBP_N_2; 1.
DR PROSITE; PS00484; THYROGLOBULIN_1_1; 1.
DR PROSITE; PS51162; THYROGLOBULIN_1_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Disulfide bond; Growth factor binding;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..265
FT /note="Insulin-like growth factor-binding protein 5"
FT /id="PRO_0000223894"
FT DOMAIN 24..104
FT /note="IGFBP N-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00653"
FT DOMAIN 182..256
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00500"
FT REGION 111..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 46..60
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00500"
FT DISULFID 68..81
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00500"
FT DISULFID 185..212
FT /evidence="ECO:0000250|UniProtKB:P24593,
FT ECO:0000255|PROSITE-ProRule:PRU00500"
FT DISULFID 223..234
FT /evidence="ECO:0000250|UniProtKB:P24593,
FT ECO:0000255|PROSITE-ProRule:PRU00500"
FT DISULFID 236..256
FT /evidence="ECO:0000250|UniProtKB:P24593,
FT ECO:0000255|PROSITE-ProRule:PRU00500"
SQ SEQUENCE 265 AA; 29995 MW; E0B943382778A8DA CRC64;
MEMLLPMCLL LVSLCLGQCQ ALGSFVHCEP CDDKAMSMCP PTPVGCELVK EPGCGCCMTC
ALAEGHRCGV YTEHCAKGLR CLPEQGEEKP LHALLHGRGV CLNLKNHRDQ SKIDRESREE
DPTTSETEDI YQSKHRGKMR LSDQKAIALN TFRQKKHSQS RIVSVEKVQS PSTPEHSIEI
DMGPCRRQVE TLMQEMKLSH RVYPRAFYLP NCDRKGFYKR KQCKPSRGRK RGLCWCVDKY
GLKLPGIDYV NGDLQCHSFD SSNTE
