IBPA_SHIF8
ID IBPA_SHIF8 Reviewed; 137 AA.
AC Q0SYN0;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=Small heat shock protein IbpA {ECO:0000255|HAMAP-Rule:MF_02000};
DE AltName: Full=16 kDa heat shock protein A {ECO:0000255|HAMAP-Rule:MF_02000};
GN Name=ibpA {ECO:0000255|HAMAP-Rule:MF_02000}; OrderedLocusNames=SFV_3824;
OS Shigella flexneri serotype 5b (strain 8401).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=373384;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=8401;
RX PubMed=16822325; DOI=10.1186/1471-2164-7-173;
RA Nie H., Yang F., Zhang X., Yang J., Chen L., Wang J., Xiong Z., Peng J.,
RA Sun L., Dong J., Xue Y., Xu X., Chen S., Yao Z., Shen Y., Jin Q.;
RT "Complete genome sequence of Shigella flexneri 5b and comparison with
RT Shigella flexneri 2a.";
RL BMC Genomics 7:173-173(2006).
CC -!- FUNCTION: Associates with aggregated proteins, together with IbpB, to
CC stabilize and protect them from irreversible denaturation and extensive
CC proteolysis during heat shock and oxidative stress. Aggregated proteins
CC bound to the IbpAB complex are more efficiently refolded and
CC reactivated by the ATP-dependent chaperone systems ClpB and
CC DnaK/DnaJ/GrpE. Its activity is ATP-independent. {ECO:0000255|HAMAP-
CC Rule:MF_02000}.
CC -!- SUBUNIT: Monomer. Forms homomultimers of about 100-150 subunits at
CC optimal growth temperatures. Conformation changes to monomers at high
CC temperatures or high ionic concentrations. {ECO:0000255|HAMAP-
CC Rule:MF_02000}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_02000}.
CC -!- SIMILARITY: Belongs to the small heat shock protein (HSP20) family.
CC {ECO:0000255|HAMAP-Rule:MF_02000, ECO:0000255|PROSITE-
CC ProRule:PRU00285}.
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DR EMBL; CP000266; ABF05835.1; -; Genomic_DNA.
DR RefSeq; WP_001243437.1; NC_008258.1.
DR AlphaFoldDB; Q0SYN0; -.
DR SMR; Q0SYN0; -.
DR EnsemblBacteria; ABF05835; ABF05835; SFV_3824.
DR GeneID; 67417682; -.
DR KEGG; sfv:SFV_3824; -.
DR HOGENOM; CLU_046737_4_2_6; -.
DR OMA; TAHDNML; -.
DR BioCyc; SFLE373384:SFV_RS21075-MON; -.
DR Proteomes; UP000000659; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0050821; P:protein stabilization; IEA:UniProtKB-UniRule.
DR CDD; cd06470; ACD_IbpA-B_like; 1.
DR Gene3D; 2.60.40.790; -; 1.
DR HAMAP; MF_02000; HSP20_IbpA; 1.
DR InterPro; IPR002068; A-crystallin/Hsp20_dom.
DR InterPro; IPR037913; ACD_IbpA/B.
DR InterPro; IPR008978; HSP20-like_chaperone.
DR InterPro; IPR023728; HSP20_IbpA.
DR Pfam; PF00011; HSP20; 1.
DR SUPFAM; SSF49764; SSF49764; 1.
DR PROSITE; PS01031; SHSP; 1.
PE 3: Inferred from homology;
KW Chaperone; Cytoplasm; Stress response.
FT CHAIN 1..137
FT /note="Small heat shock protein IbpA"
FT /id="PRO_1000022025"
FT DOMAIN 28..137
FT /note="sHSP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00285"
SQ SEQUENCE 137 AA; 15774 MW; E7BB51421F5CEF3E CRC64;
MRNFDLSPLY RSAIGFDRLF NHLENNQSQS NGGYPPYNVE LVDENHYRIA IAVAGFAESE
LEITAQDNLL VVKGAHADEQ KERTYLYQGI AERNFERKFQ LAENIHVRGA NLVNGLLYID
LERVIPEAKK PRRIEIN
