ID   IBPL1_BOVIN             Reviewed;         274 AA.
AC   A5PKD8;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Insulin-like growth factor-binding protein-like 1;
DE   Flags: Precursor;
GN   Name=IGFBPL1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: IGF-binding proteins prolong the half-life of IGFs and have
CC       been shown to either inhibit or stimulate the growth promoting effects
CC       of the IGFs in cell culture. They alter the interaction of IGFs with
CC       their cell surface receptors (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
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DR   EMBL; BC142451; AAI42452.1; -; mRNA.
DR   RefSeq; NP_001092631.1; NM_001099161.2.
DR   AlphaFoldDB; A5PKD8; -.
DR   SMR; A5PKD8; -.
DR   STRING; 9913.ENSBTAP00000018719; -.
DR   PaxDb; A5PKD8; -.
DR   Ensembl; ENSBTAT00000018719; ENSBTAP00000018719; ENSBTAG00000014078.
DR   GeneID; 616886; -.
DR   KEGG; bta:616886; -.
DR   CTD; 347252; -.
DR   VEuPathDB; HostDB:ENSBTAG00000014078; -.
DR   VGNC; VGNC:30090; IGFBPL1.
DR   eggNOG; ENOG502QSKF; Eukaryota.
DR   GeneTree; ENSGT00530000063555; -.
DR   HOGENOM; CLU_075590_0_1_1; -.
DR   InParanoid; A5PKD8; -.
DR   OMA; IAARDEC; -.
DR   OrthoDB; 994901at2759; -.
DR   TreeFam; TF331645; -.
DR   Proteomes; UP000009136; Chromosome 8.
DR   Bgee; ENSBTAG00000014078; Expressed in Ammon's horn and 33 other tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005520; F:insulin-like growth factor binding; IEA:InterPro.
DR   GO; GO:0071228; P:cellular response to tumor cell; IEA:Ensembl.
DR   GO; GO:0001558; P:regulation of cell growth; IEA:InterPro.
DR   GO; GO:0009966; P:regulation of signal transduction; IBA:GO_Central.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR000867; IGFBP-like.
DR   InterPro; IPR011390; IGFBP_rP_mac25.
DR   InterPro; IPR002350; Kazal_dom.
DR   InterPro; IPR036058; Kazal_dom_sf.
DR   PANTHER; PTHR14186; PTHR14186; 1.
DR   Pfam; PF00219; IGFBP; 1.
DR   Pfam; PF07648; Kazal_2; 1.
DR   PIRSF; PIRSF018239; IGFBP_rP_mac25; 1.
DR   SMART; SM00121; IB; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00408; IGc2; 1.
DR   SMART; SM00280; KAZAL; 1.
DR   SUPFAM; SSF100895; SSF100895; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   SUPFAM; SSF57184; SSF57184; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS51323; IGFBP_N_2; 1.
DR   PROSITE; PS51465; KAZAL_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Immunoglobulin domain; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..274
FT                   /note="Insulin-like growth factor-binding protein-like 1"
FT                   /id="PRO_0000297686"
FT   DOMAIN          30..105
FT                   /note="IGFBP N-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00653"
FT   DOMAIN          91..149
FT                   /note="Kazal-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT   DOMAIN          151..255
FT                   /note="Ig-like C2-type"
FT   CARBOHYD        162
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        111..147
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT   DISULFID        172..239
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   274 AA;  28673 MW;  B7046C22C270F397 CRC64;
     MPRSPGLFLL LLVLQPLPAL GLGLRSAGGR NPECGPCRPE RCPEPVRCPV PGIVARDECG
     CCALCLGAEG ASCGGRAGAR CGPGLVCASR AAGAAPEGTG LCVCAQRGSV CGSDGRSYPS
     VCALRLRARQ APRALPGHLH KARDGPCEFA PVVITPPQSV HNVTGAQVYL SCEVRAVPTP
     VVTWRKVTRS PEGTQVMEEL PGDHTNIAVQ VQGGPSDHEA TAWVLINPLR KEDEGVYQCH
     SANAVGEAQS HGTVTVVDRS QYRAPRFPAP DDRL