IBPL1_MOUSE
ID IBPL1_MOUSE Reviewed; 270 AA.
AC Q80W15;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Insulin-like growth factor-binding protein-like 1;
DE AltName: Full=IGFBP-related protein 10;
DE AltName: Full=Insulin-like growth factor-binding-related protein 4;
DE Short=IGFBP-rP4;
DE Flags: Precursor;
GN Name=Igfbpl1; Synonyms=Igfbprp4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: IGF-binding proteins prolong the half-life of IGFs and have
CC been shown to either inhibit or stimulate the growth promoting effects
CC of the IGFs in cell culture. They alter the interaction of IGFs with
CC their cell surface receptors (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
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DR EMBL; AL772381; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC051960; AAH51960.1; -; mRNA.
DR CCDS; CCDS38756.1; -.
DR RefSeq; NP_061211.1; NM_018741.2.
DR AlphaFoldDB; Q80W15; -.
DR SMR; Q80W15; -.
DR STRING; 10090.ENSMUSP00000036974; -.
DR GlyGen; Q80W15; 1 site.
DR PhosphoSitePlus; Q80W15; -.
DR MaxQB; Q80W15; -.
DR PaxDb; Q80W15; -.
DR PRIDE; Q80W15; -.
DR ProteomicsDB; 267037; -.
DR Antibodypedia; 62957; 57 antibodies from 16 providers.
DR Ensembl; ENSMUST00000044297; ENSMUSP00000036974; ENSMUSG00000035551.
DR GeneID; 75426; -.
DR KEGG; mmu:75426; -.
DR UCSC; uc008ssy.1; mouse.
DR CTD; 347252; -.
DR MGI; MGI:1933198; Igfbpl1.
DR VEuPathDB; HostDB:ENSMUSG00000035551; -.
DR eggNOG; ENOG502QSKF; Eukaryota.
DR GeneTree; ENSGT00530000063555; -.
DR HOGENOM; CLU_075590_0_1_1; -.
DR InParanoid; Q80W15; -.
DR OMA; IAARDEC; -.
DR OrthoDB; 994901at2759; -.
DR PhylomeDB; Q80W15; -.
DR TreeFam; TF331645; -.
DR BioGRID-ORCS; 75426; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Igfbpl1; mouse.
DR PRO; PR:Q80W15; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q80W15; protein.
DR Bgee; ENSMUSG00000035551; Expressed in cortical plate and 70 other tissues.
DR Genevisible; Q80W15; MM.
DR GO; GO:0005615; C:extracellular space; ISO:MGI.
DR GO; GO:0005520; F:insulin-like growth factor binding; IEA:InterPro.
DR GO; GO:0071228; P:cellular response to tumor cell; IEA:Ensembl.
DR GO; GO:0001558; P:regulation of cell growth; IEA:InterPro.
DR GO; GO:0009966; P:regulation of signal transduction; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR000867; IGFBP-like.
DR InterPro; IPR011390; IGFBP_rP_mac25.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR PANTHER; PTHR14186; PTHR14186; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF00219; IGFBP; 1.
DR Pfam; PF00050; Kazal_1; 1.
DR PIRSF; PIRSF018239; IGFBP_rP_mac25; 1.
DR SMART; SM00121; IB; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00280; KAZAL; 1.
DR SUPFAM; SSF100895; SSF100895; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR SUPFAM; SSF57184; SSF57184; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51323; IGFBP_N_2; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Immunoglobulin domain; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT CHAIN 18..270
FT /note="Insulin-like growth factor-binding protein-like 1"
FT /id="PRO_0000297688"
FT DOMAIN 26..101
FT /note="IGFBP N-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00653"
FT DOMAIN 87..145
FT /note="Kazal-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT DOMAIN 147..251
FT /note="Ig-like C2-type"
FT CARBOHYD 158
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 107..143
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT DISULFID 168..235
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ SEQUENCE 270 AA; 28573 MW; 2F1DEE6C6A3C1A77 CRC64;
MPRLPLLLLL LPSLARGLGL RDAGRRHPEC SPCQQDRCPA PSPCPAPWIS ARDECGCCAR
CLGAEGASCG GPVGSRCGPG LVCASRASGT APEGTGLCVC AQRGAVCGSD GRSYSSICAL
RLRARHAPRA HHGHLHKARD GPCEFAPVVL MPPRDIHNVT GTQVFLSCEV KAVPTPVITW
KKVKHSPEGT EGLEELPGDH VNIAVQVRGG PSDHETTSWI LINPLRKEDE GVYHCHAANA
IGEAQSHGTV TVLDLNRYKS LYSSVPGDLL
