ID   IBPS_BOVIN              Reviewed;          60 AA.
AC   P00975;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Serum basic protease inhibitor;
DE            Short=Serum BPI;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=7428928; DOI=10.1016/0014-5793(80)80997-5;
RA   Wachter E., Deppner K., Hochstrasser K., Lempart K., Geiger R.;
RT   "A new Kunitz-type inhibitor from bovine serum amino acid sequence
RT   determination.";
RL   FEBS Lett. 119:58-62(1980).
CC   -!- FUNCTION: This inhibitor has activity very similar to that of the basic
CC       protease inhibitor from bovine tissues.
CC   -!- SUBCELLULAR LOCATION: Secreted.
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DR   PIR; A01206; TIBOR.
DR   AlphaFoldDB; P00975; -.
DR   SMR; P00975; -.
DR   MEROPS; I02.004; -.
DR   PRIDE; P00975; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central.
DR   CDD; cd00109; KU; 1.
DR   Gene3D; 4.10.410.10; -; 1.
DR   InterPro; IPR002223; Kunitz_BPTI.
DR   InterPro; IPR036880; Kunitz_BPTI_sf.
DR   InterPro; IPR020901; Prtase_inh_Kunz-CS.
DR   Pfam; PF00014; Kunitz_BPTI; 1.
DR   PRINTS; PR00759; BASICPTASE.
DR   SMART; SM00131; KU; 1.
DR   SUPFAM; SSF57362; SSF57362; 1.
DR   PROSITE; PS00280; BPTI_KUNITZ_1; 1.
DR   PROSITE; PS50279; BPTI_KUNITZ_2; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Protease inhibitor;
KW   Reference proteome; Secreted; Serine protease inhibitor.
FT   CHAIN           1..60
FT                   /note="Serum basic protease inhibitor"
FT                   /id="PRO_0000155408"
FT   DOMAIN          7..57
FT                   /note="BPTI/Kunitz inhibitor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT   SITE            17..18
FT                   /note="Reactive bond"
FT   DISULFID        7..57
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT   DISULFID        16..40
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT   DISULFID        32..53
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
SQ   SEQUENCE   60 AA;  6647 MW;  B9953EBAACF1A4E6 CRC64;
     TERPDFCLEP PYTGPCKAAM IRYFYNAKAG FCETFVYGGC RAKSNNFKSA EDCMRTCGGA