ID   IBP_CARCR               Reviewed;         110 AA.
AC   P00993;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Chelonianin;
DE   AltName: Full=Basic protease inhibitor;
DE   AltName: Full=RTPI;
OS   Caretta caretta (Loggerhead sea turtle).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC   Americhelydia; Chelonioidea; Cheloniidae; Caretta.
OX   NCBI_TaxID=8467;
RN   [1]
RP   PROTEIN SEQUENCE, AND PYROGLUTAMATE FORMATION AT GLN-1.
RC   TISSUE=Egg white;
RA   Kato I., Tominaga N.;
RT   "Trypsin-subtilisin inhibitor from red sea turtle eggwhite consists of two
RT   tandem domains -- one Kunitz -- one of a new family.";
RL   Fed. Proc. 38:832-832(1979).
CC   -!- FUNCTION: The first domain inhibits trypsin; the second one inhibitis
CC       subtilisin.
CC   -!- CAUTION: As the paper only indicates the species as 'red sea turtle',
CC       the species indicated here is therefore an inference. {ECO:0000305}.
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DR   PIR; A01224; TITTOR.
DR   AlphaFoldDB; P00993; -.
DR   SMR; P00993; -.
DR   MEROPS; I02.022; -.
DR   MEROPS; I17.004; -.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   CDD; cd00109; KU; 1.
DR   Gene3D; 4.10.410.10; -; 1.
DR   Gene3D; 4.10.75.10; -; 1.
DR   InterPro; IPR036645; Elafin-like_sf.
DR   InterPro; IPR002223; Kunitz_BPTI.
DR   InterPro; IPR036880; Kunitz_BPTI_sf.
DR   InterPro; IPR020901; Prtase_inh_Kunz-CS.
DR   InterPro; IPR008197; WAP_dom.
DR   Pfam; PF00014; Kunitz_BPTI; 1.
DR   Pfam; PF00095; WAP; 1.
DR   PRINTS; PR00003; 4DISULPHCORE.
DR   PRINTS; PR00759; BASICPTASE.
DR   SMART; SM00131; KU; 1.
DR   SMART; SM00217; WAP; 1.
DR   SUPFAM; SSF57256; SSF57256; 1.
DR   SUPFAM; SSF57362; SSF57362; 1.
DR   PROSITE; PS00280; BPTI_KUNITZ_1; 1.
DR   PROSITE; PS50279; BPTI_KUNITZ_2; 1.
DR   PROSITE; PS51390; WAP; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Protease inhibitor;
KW   Pyrrolidone carboxylic acid; Serine protease inhibitor.
FT   CHAIN           1..110
FT                   /note="Chelonianin"
FT                   /id="PRO_0000155409"
FT   DOMAIN          8..58
FT                   /note="BPTI/Kunitz inhibitor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT   DOMAIN          60..105
FT                   /note="WAP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT   SITE            18..19
FT                   /note="Reactive bond for trypsin"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|Ref.1"
FT   DISULFID        8..58
FT                   /evidence="ECO:0000250"
FT   DISULFID        17..41
FT                   /evidence="ECO:0000250"
FT   DISULFID        33..54
FT                   /evidence="ECO:0000250"
FT   DISULFID        67..92
FT                   /evidence="ECO:0000250"
FT   DISULFID        76..97
FT                   /evidence="ECO:0000250"
FT   DISULFID        80..93
FT                   /evidence="ECO:0000250"
FT   DISULFID        86..101
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   110 AA;  11916 MW;  269436243813418E CRC64;
     QGDKRDICRL PPEQGPCKGR IPRYFYNPAS RMCESFIYGG CKGNKNNFKT KAECVRACRP
     PERPGVCPKT SGPGICLHGC DSDSDCKEGQ KCCFDGCGYI CLTVAPSGSP