IBSE_ECOLI
ID IBSE_ECOLI Reviewed; 19 AA.
AC C1P617;
DT 13-OCT-2009, integrated into UniProtKB/Swiss-Prot.
DT 26-MAY-2009, sequence version 1.
DT 03-AUG-2022, entry version 41.
DE RecName: Full=Small toxic protein IbsE;
GN Name=ibsE; OrderedLocusNames=b4666, JW3023.2;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [3]
RP IDENTIFICATION, FUNCTION, OVEREXPRESSION, AND DISRUPTION PHENOTYPE.
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=18710431; DOI=10.1111/j.1365-2958.2008.06394.x;
RA Fozo E.M., Kawano M., Fontaine F., Kaya Y., Mendieta K.S., Jones K.L.,
RA Ocampo A., Rudd K.E., Storz G.;
RT "Repression of small toxic protein synthesis by the Sib and OhsC small
RT RNAs.";
RL Mol. Microbiol. 70:1076-1093(2008).
CC -!- FUNCTION: Toxic component of a type I toxin-antitoxin (TA) system.
CC Overexpression causes cessation of growth.
CC {ECO:0000269|PubMed:18710431}.
CC -!- INDUCTION: The sibE sRNA probably represses expression of ibsE mRNA,
CC either by destabilizing the transcript and/or preventing its
CC translation. Expression of the proteinaceous toxin is controlled by
CC antisense sRNA SibE.
CC -!- DISRUPTION PHENOTYPE: None seen. An isbE overproducing strain cannot be
CC made in the absence of the sibE gene. {ECO:0000269|PubMed:18710431}.
CC -!- MISCELLANEOUS: Part of the SIBe repeat region, encoded on the opposite
CC strand from the sibE RNA.
CC -!- SIMILARITY: Belongs to the Ibs toxic protein family. {ECO:0000305}.
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DR EMBL; U00096; ACO60009.1; -; Genomic_DNA.
DR EMBL; AP009048; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; WP_010723221.1; NZ_SSZK01000028.1.
DR RefSeq; YP_002791257.1; NC_000913.3.
DR AlphaFoldDB; C1P617; -.
DR PaxDb; C1P617; -.
DR PRIDE; C1P617; -.
DR EnsemblBacteria; ACO60009; ACO60009; b4666.
DR GeneID; 7751629; -.
DR KEGG; eco:b4666; -.
DR BioCyc; EcoCyc:MON0-2855; -.
DR PRO; PR:C1P617; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0012501; P:programmed cell death; IMP:EcoCyc.
DR InterPro; IPR025881; Toxin_Ibs.
DR Pfam; PF13956; Ibs_toxin; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Toxin-antitoxin system.
FT CHAIN 1..19
FT /note="Small toxic protein IbsE"
FT /id="PRO_0000386424"
SQ SEQUENCE 19 AA; 2207 MW; 792BA438C3C048F7 CRC64;
MMKLVIILVV LLLLSFPTY