ICA1L_MOUSE
ID ICA1L_MOUSE Reviewed; 431 AA.
AC Q3TY65; Q6AXB8; Q6PD23; Q8C0R6; Q9D9S5;
DT 24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Islet cell autoantigen 1-like protein;
DE AltName: Full=Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 15 protein homolog;
DE AltName: Full=Ica69-related protein;
GN Name=Ica1l; Synonyms=Als2cr15;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis, and Visual cortex;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryonic brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB24634.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK006525; BAB24634.1; ALT_INIT; mRNA.
DR EMBL; AK029991; BAC26721.1; -; mRNA.
DR EMBL; AK158859; BAE34698.1; -; mRNA.
DR EMBL; BC058983; AAH58983.1; -; mRNA.
DR EMBL; BC079669; AAH79669.1; -; mRNA.
DR CCDS; CCDS14987.1; -.
DR RefSeq; NP_001303623.1; NM_001316694.1.
DR RefSeq; NP_081683.3; NM_027407.4.
DR RefSeq; XP_006496332.1; XM_006496269.3.
DR RefSeq; XP_006496333.1; XM_006496270.2.
DR RefSeq; XP_011236899.1; XM_011238597.2.
DR AlphaFoldDB; Q3TY65; -.
DR STRING; 10090.ENSMUSP00000027172; -.
DR iPTMnet; Q3TY65; -.
DR PhosphoSitePlus; Q3TY65; -.
DR MaxQB; Q3TY65; -.
DR PaxDb; Q3TY65; -.
DR PeptideAtlas; Q3TY65; -.
DR PRIDE; Q3TY65; -.
DR ProteomicsDB; 267185; -.
DR Antibodypedia; 34156; 102 antibodies from 20 providers.
DR DNASU; 70375; -.
DR Ensembl; ENSMUST00000027172; ENSMUSP00000027172; ENSMUSG00000026018.
DR Ensembl; ENSMUST00000191251; ENSMUSP00000140520; ENSMUSG00000026018.
DR GeneID; 70375; -.
DR KEGG; mmu:70375; -.
DR UCSC; uc007beb.1; mouse.
DR CTD; 130026; -.
DR MGI; MGI:1917625; Ica1l.
DR VEuPathDB; HostDB:ENSMUSG00000026018; -.
DR eggNOG; KOG3891; Eukaryota.
DR GeneTree; ENSGT00390000005530; -.
DR HOGENOM; CLU_037158_1_0_1; -.
DR InParanoid; Q3TY65; -.
DR OMA; RIHEEFT; -.
DR OrthoDB; 766523at2759; -.
DR PhylomeDB; Q3TY65; -.
DR TreeFam; TF317186; -.
DR BioGRID-ORCS; 70375; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Ica1l; mouse.
DR PRO; PR:Q3TY65; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q3TY65; protein.
DR Bgee; ENSMUSG00000026018; Expressed in spermatid and 102 other tissues.
DR ExpressionAtlas; Q3TY65; baseline and differential.
DR Genevisible; Q3TY65; MM.
DR GO; GO:0001669; C:acrosomal vesicle; IDA:MGI.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0019904; F:protein domain specific binding; IEA:InterPro.
DR GO; GO:0051049; P:regulation of transport; IBA:GO_Central.
DR GO; GO:0007286; P:spermatid development; IMP:MGI.
DR Gene3D; 1.20.1270.60; -; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR010504; AH_dom.
DR InterPro; IPR024114; Islet_autoAg_Ica1/Ica1-like.
DR InterPro; IPR006723; Islet_autoAg_Ica1_C.
DR PANTHER; PTHR10164; PTHR10164; 2.
DR Pfam; PF06456; Arfaptin; 1.
DR Pfam; PF04629; ICA69; 2.
DR SMART; SM01015; Arfaptin; 1.
DR SMART; SM01237; ICA69; 1.
DR SUPFAM; SSF103657; SSF103657; 1.
DR PROSITE; PS50870; AH; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..431
FT /note="Islet cell autoantigen 1-like protein"
FT /id="PRO_0000076176"
FT DOMAIN 44..247
FT /note="AH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00294"
FT REGION 295..316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 351..372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 29
FT /note="V -> A (in Ref. 2; AAH79669)"
FT /evidence="ECO:0000305"
FT CONFLICT 137
FT /note="F -> I (in Ref. 1; BAB24634)"
FT /evidence="ECO:0000305"
FT CONFLICT 244
FT /note="Q -> H (in Ref. 1; BAB24634)"
FT /evidence="ECO:0000305"
FT CONFLICT 356
FT /note="T -> S (in Ref. 1; BAC26721)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 431 AA; 48160 MW; D2C80875BB7087F8 CRC64;
MDSSEQLRAE DNQSVVSRMQ KNYWRTKQVF IKATGKKEDE HVVASDAELD AKLEVFHSIQ
ETCNELVKIV EKYQLRLNVI SEEENELGLF LKFQAERDST QAGEMMDAAG KALCSSAKQR
LALCTPLSRL KQEVATFSQR AISDTLVTIN RMERARTEYR GALLWMKDAS QELDPDTFKQ
MEKFRKVQNQ VRNSKDSFDK LKKDVCQKVD LLGASRCNML SHSLTTYQRT LLGFWEKTAQ
MMTQIQEACA GFHPYDFLAL KRLQDTPGNL TADCTEGQTE GSCLTTDLNK VALSEEEEEE
RFEREPAVAR ALPRDSLEGD DFEKEFSFLN SLLSPTSSSA SEFTQECQPA CGSPCTGLTS
QEPSVGPGSL TSSSQFLPSQ LFDLGLHADG AFNTPNNGNQ DMSAWFNLFA DLGPLSNPDA
IGHSDDELLN A
